Abstract: System and method are provided for achieving “inverse kinematics” of 3D graphics depicting an object that consists of multiple parts. The system displays an animation of a 3D graphics object that consists of multiple moving parts. The animation is associated with an animation timeline defined by two end points—a starting time point and an ending time point. The user can manipulate the object back and forth along the animation timeline, between the two end points, by selecting (e.g., clicking on) and moving (dragging) any of the movable parts of the object on a display screen. In short, the user can use any of the movable parts as a scroll/slide button to move the animation forward and backward along the animation timeline, to achieve real-time inverse kinematics movement.

Abstract: System and method are provided for building and rendering a 3D graphics dataset of an object that consists of multiple parts, wherein the 3D graphics dataset includes a 3D geometry dataset and a configuration file, and in the configuration file each of the multiple parts is identified as used (e.g., visible, actionable) or unused (e.g., not visible, not actionable) in each of multiple display features (e.g., in display states, such as in animations, or in display relationships). The method determines which of the multiple parts are unused in each of the multiple display features and identifies those parts, which are unused in all of the display features, as excluded parts, and saves a list of the identified excluded parts in association with the object. In rendering the object on a display, the method does not load data directed to the excluded parts, to thereby speed up the loading/rendering process.

Abstract: System and method are provided for building and rendering a 3D graphics dataset of an object that consists of multiple parts, wherein the 3D graphics dataset includes a 3D geometry dataset and a configuration file, and in the configuration file each of the multiple parts is identified as used (e.g., visible, actionable) or unused (e.g., not visible, not actionable) in each of multiple display features (e.g., in display states, such as in animations, or in display relationships). The method determines which of the multiple parts are unused in each of the multiple display features and identifies those parts, which are unused in all of the display features, as excluded parts, and saves a list of the identified excluded parts in association with the object. In rendering the object on a display, the method does not load data directed to the excluded parts, to thereby speed up the loading/rendering process.

Abstract: System and method are provided for achieving “inverse kinematics” of 3D graphics depicting an object that consists of multiple parts. The system displays an animation of a 3D graphics object that consists of multiple moving parts. The animation is associated with an animation timeline defined by two end points—a starting time point and an ending time point. The user can manipulate the object back and forth along the animation timeline, between the two end points, by selecting (e.g., clicking on) and moving (dragging) any of the movable parts of the object on a display screen. In short, the user can use any of the movable parts as a scroll/slide button to move the animation forward and backward along the animation timeline, to achieve real-time inverse kinematics movement.

Abstract: The invention relates a method of treating amyloidosis, diseases and disorders associated with amyloid plaque formation, e.g., Alzheimer's disease by increasing tissue resident macrophage activity in an organ or tissue of an animal requiring treatment by systemic administration of a colony stimulating factor. For example, the activity of bone marrow-derived microglial cells in an organ or tissue can be increased by systemic administration of a colony stimulating factor, particularly macrophage colony stimulating factor, either alone or in combination with additional colony stimulating factors, stem cell factors or other compounds capable of treating amyloidosis.

Abstract: This application relates to antibodies reactive with a novel homogenous human cytokine, Natural Killer Stimulator Factor (NKSF), having the ability to induce the production of gamia interferon in vitro in human peripheral blood lymphocytes, and a pharmaceutical preparation containing such antibodies.

Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.

Abstract: Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

Abstract: This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample.

Abstract: This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample.

Abstract: Disclosed is a family of novel protein constructs, useful as drugs and for other purposes, termed “adzymes,” comprising an address moiety and a catalytic domain. In some types of disclosed adzymes, the address binds with a binding site on or in functional proximity to a targeted biomolecule, e.g., an extracellular targeted biomolecule, and is disposed adjacent the catalytic domain so that its affinity serves to confer a new specificity to the catalytic domain by increasing the effective local concentration of the target in the vicinity of the catalytic domain. The present invention also provides pharmaceutical compositions comprising these adzymes, methods of making adzymes, DNA's encoding adzymes or parts thereof, and methods of using adzymes, such as for treating human subjects suffering from a disease, such as a disease associated with a soluble or membrane bound molecule, e.g., an allergic or inflammatory disease.

Abstract: Novel means and methods for analyzing hybridization data derived from hybridization assays between a target nucleic acid and differently sequenced polynucleotide probes involve selecting probe sets that define reference sequences for sequence signatures and deriving useful data about the nature of the target nucleic acid molecule based on its hybridization to the probes. The methods are useful for determining whether the target contains a nucleic acid or polypeptide sequence signature, whether the target encodes a member of a gene family, or whether the target is derived from one of any number of genes.

Abstract: Novel polynucleotides and the proteins encoded thereby are disclosed.

Abstract: This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample.

Abstract: This invention provides methods of monitoring the expression levels of a multiplicity of genes. The methods involve hybridizing a nucleic acid sample to a high density array of oligonucleotide probes where the high density array contains oligonucleotide probes complementary to subsequences of target nucleic acids in the nucleic acid sample.