Abstract: A blood detoxification apparatus comprises a housing filled with a plurality of substantially spherical reaction bodies. Each reaction body comprises an embedding material and active ingredient particles such as adsorbents and/or enzymes embedded in the embedding material which is blood compatible but nonpermeable for corpuscular blood components. The active ingredients may have a dust or powder or granular consistency but are substantially smaller in diameter than the reaction bodies which may be distributed in layers in said housing whereby the active ingredients in different layers may be different.