Patents by Inventor Ágota Smelkóné Esek

Ágota Smelkóné Esek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of spiro[(4-cyclohexanone)-[3]indol]-2?[1?H]-one derivatives
    Patent number: 6884895
    Abstract: The invention relates to a process for the preparation of spiro[(4-cyclohexanone)-[3H]indol]-2?[1?H]-one derivatives of the general formula I wherein R1 and R2 independently stand for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluoroalkyl, C1-4polyfluoroalkoxy, C3-7cycloalkyloxy, C3-7cycloalkylthio, phenoxy, benzyloxy or nitro group—, characterized by reacting an indolin-2-one derivative of the general formula II wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, selected from 2-tetrahydropyranyl, 1-diethoxy-methylene or C1-4alkoxycarbonylethyl group, coupling the compound of general formula III, thus obtained—wherein R1 and R2 are as defined above and A stands for a protective group, selected from 2-tetrahydropyranyl, 1-diethoxy-methylene or C1-4alkoxycarbonylethyl group—with an acrylic acid C1-4ester, cyclizing the resulting compound of the general formula IV wherein R1, R2 and A are as defined above, R3 stands for C1-4 alkyl grou
    Type: Grant
    Filed: April 8, 2003
    Date of Patent: April 26, 2005
    Assignee: sanofi-aventis
    Inventors: Csaba Gönczi, Éva Csikós, István Hermecz, Gergely Héja, Árpád Illár, Lajos Nagy, Andrea Sántáné Csutor, Attila Simon, Kálmán Simon, Ágota Smelkóné Esek, Tiborné Szomor, Györgyné Szvoboda
  • New process for the preparation of spiro[(4-cyclohexanone)-[3H]indol-2'[1'H]-one derivatives
    Publication number: 20030212278
    Abstract: The invention relates to a process for the preparation of spiro[(4-cyclohexanone)-[3H]indol]-2′[1′H]-one derivatives of the general formula I 1
    Type: Application
    Filed: April 8, 2003
    Publication date: November 13, 2003
    Inventors: Csaba Gonczi, Eva Csikos, Istvan Hermecz, Gergely Heja, Arpad Illar, Lajos Nagy, Andrea Santane Csutor, Attila Simon, Kalman Simon, Agota Smelkone Esek, Tiborne Szomor, Gyorgyne Szvoboda
  • Therapeutically useful new salts of cck inhibitors, process for the preparation thereof and pharmaceutical preparations containing them
    Publication number: 20030176475
    Abstract: New salts of the general formula (I), their solvates, polymorphs and pseudo polymorphs wherein X stands for ethanolamine, diethanolamine or diethylamine.
    Type: Application
    Filed: February 19, 2003
    Publication date: September 18, 2003
    Inventors: Istvan Hermecz, Agnes Horvath, Gyulane Kiss, Miklos Morvai, Benjamin Podanyi, Kalman Simon, Judit Sipos, Agota Smelkone Esek, Anna Szabo, Arpadne Vasvari
  • Process for the preparation of spiro[(4-cyclohexanone)-[3H]indol]-2?[1?H]-one derivatives
    Patent number: 6573386
    Abstract: The invention relates to a process for the preparation of spiro [(4-cyclohexanone)-[3H]indol]-2′[1′H]-one derivatives of general formula I—wherein R1 and R2 independently stand for hydrogen, C1-4alkyl, C1-4alkoxy, C1-4alkylthio, C1-4polyfluoroalkyl, C1-4polyfluoroalkoxy, C3-7cycloalkyloxy, C3-7cycloalkylthio, phenoxy, benzyloxy or nitro group—, characterized by reacting an indolin-2-one derivative of general formula II—wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, coupling the compound of general formula III, thus obtained—wherein R1 and R2 are as defined above and A stands for a protective group—with acrylic acid C1-4ester; cyclizing the resulting compound of general formula IV—wherein R1 and R2 are as defined above—with a compound capable for introducing a protective group, coupling the compound of formula III thus obtained,—wherein R1 and R2 are as defined abo
    Type: Grant
    Filed: April 17, 2002
    Date of Patent: June 3, 2003
    Assignee: Sanofi-Synthelabo
    Inventors: Csaba Gönczi, Éva Csikós, István Hermecz, Gergely Héja, Árpád Illár, Lajos Nagy, Andrea Sántáné Csutor, Attila Simon, Kálmán Simon, Ágota Smelkóné Esek, Tiborné Szomor, Györgyné Szvoboda
  • Method for the preparation of 2-methoxy-4-(N-t-butylamino-carbonyl)-benzenesulfonyl chloride
    Patent number: 6548702
    Abstract: The invention relates to a process for the preparation of 2-methoxy-4-(N-t-butylaminocarbonyl)benzenesulfonyl chloride by sulfonating m-hydroxybenzoic acid, methylating the hydroxy group of the resulting sulfonic acid or its salt, transforming the carboxylic acid group and the sulfonic acid group to acid chloride groups and reacting the 4-chlorosulfonyl-3-methoxy-benzoyl chloride with t-butylamine, which comprises carrying out the sulfonation of the 3-methoxy-benzoic acid of general formula (II) with 96% sulfuric acid, separating the resulting 3-hydroxy-4-sulfobenzoic acid of general formula (III) in the form of its salt of general formula (IV), wherein Z stands for alkali metal or ammonium group, methylating the compound of general formula (IV) in the presence of a phase transfer catalyst at a pH value of about 11.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: April 15, 2003
    Assignee: Sanofi-Synthelabo
    Inventors: Csaba Gönczi, Éva Csikós, Félix Hajdú, István Hermecz, Gergely Héja, Gergelyné Héja, Lajos Nagy, Andrea Sántáné Csutor, Kálmán Simon, Ágota Smelkóné Esek, Tiborné Szomor, Györgyné Szvoboda