Abstract: Disclosed in the present invention is an enzyme-free glucose detection chip for detecting blood sugar level of a blood in a neutral environment, including: a substrate; a detection portion, disposed on an end surface of the substrate; a plurality of protrusions, disposed at the detection portion; a conductive layer, disposed on a surface of the substrate having the protrusions; and a plurality of gold nanoparticles, dispersed on surfaces of the protrusions, wherein the characterized in that the conductive layer is made by mixing gold and platinum and the ratio (mol/v) of platinum to gold is 1:2 to 4:1.

Abstract: The present invention discloses a method for modifying a non-planar electrode, in which a short-chain molecule is used as a connector. The short-chain molecule is an alcohol compound having a thiol group at both ends. Therefore, the thiol groups at both the ends of the short-chain molecule can be separately bonded to a nanoparticle and a surface of an electrode, so that a plurality of nanoparticles are arranged on a surface of a non-planar electrode.

Abstract: A mitochondria extraction apparatus provided in the present invention includes a container used for holding a mixture fluid and a diafiltration assembly disposed in the container and used for isolating mitochondria. A basement of the mitochondria extraction apparatus is disposed in the container. During a circular motion of the mitochondria extraction apparatus, a centrifugal force in the mitochondria extraction apparatus acts on the mixture fluid in a hole-shaped microfluidic channel included in the diafiltration assembly, so as to provide a pushing force for the mixture fluid, enabling the mixture fluid to rapidly flow in the microfluidic channel for diafiltration.

Abstract: Disclosed in the present invention is an enzyme-free glucose detection chip, including: a substrate; a detection portion, disposed on an end surface of the substrate; a plurality of protrusions, disposed at the detection portion; a conductive layer, disposed on a surface of the substrate having the protrusions; and a plurality of gold nanoparticles, dispersed on surfaces of the protrusions. In the enzyme-free glucose detection chip disclosed in the present invention, protrusions having gold nanoparticles are used as electrodes, are structures on a micrometer scale and a nanometer scale, and can directly react with glucose without any glucose oxidase or/and any medium.

Abstract: A sensor for detecting molecular interactions between a target and a binding domain by electrochemical impedance spectroscopy. The sensor includes an anodic aluminum oxide barrier layer having a gold-coated array of regularly spaced nano-hemispheres and gold nanoparticles coated with a binding domain attached thereto. Also provided are methods for producing the sensor and for using the sensor to detect the presence of a virus in a sample.

Abstract: The present invention relates to a biosensor having a substrate, a thin-film electrode and multiple nanoparticles. The substrate has a substrate surface. The substrate surface has multiple hemispherical protrusions. The thin-film electrode is formed on the substrate surface and has multiple hemispherical surfaces. The multiple nanoparticles are electrochemically deposited on the hemispherical surfaces. The hemispherical surfaces of the thin-film electrode enlarge an area available for binding on a surface of each of the nanoparticles. The enlarged area of the nanoparticles raises the sensitivity of the biosensor and shortens detection time. The present invention also relates to a method for making the aforementioned biosensor.

Abstract: A method of determining efficiently parameters in chemical-mechanical polishing, especially a method includes a Neural-Taguchi method to seek the best parameter set to increase the quantity of output. This invention involves a time parameter to achieve end-point detection on line during the CMP procedure and also completes a maximum material removal rate (MRR) and a minimum within wafer non-uniformity (WIWNU) at the same time.

Abstract: A method of determining efficiently parameters in chemical-mechanical polishing, especially a method includes a Neural-Taguchi method to seek the best parameter set to increase the quantity of output. This invention involves a time parameter to achieve end-point detection on line during the CMP procedure and also completes a maximum material removal rate (MRR) and a minimum within wafer non-uniformity (WIWNU) at the same time.