Abstract: Provided herein are circuits and methods for processing samples of a received in-phase and quadrature (I/Q) domain signal that includes a desired signal and an interference signal that spectrally overlaps the desired signal. In the I/Q domain, a first contribution to the interference signal is removed from the samples using a first algorithm to generate first processed signal samples. Amplitudes and phases of the first processed signal samples are obtained. In an amplitude domain, a second contribution to the interference signal is removed from the amplitudes of the first processed signal samples using a second algorithm to generate second processed signal samples. A signal quality metric of the second processed signal samples is obtained. Based on the signal quality metric of the second processed signal samples, one or more parameters of the first or second algorithm are adjusted to improve the signal quality metric of the second processed signal samples.