Patents by Inventor Gourisankar GHOSH

Gourisankar GHOSH has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTI-INFLAMMATORY PEPTIDE AND METHOD OF USE THEREOF
    Publication number: 20240166703
    Abstract: The present disclosure provides a novel IKK2 inhibitor that does not target the kinase domain of IKK2 molecule. The novel IKK2 inhibitor is a cell penetrating NEMOActPep comprising a small segment (residues 384-389) of human NEMO to mediate interaction with and promote activation loop phosphorylation of IKK2. The NEMOActPep is derived from the second interaction interface of NEMO:IKK2 that is dependent upon NEMO binding to linear polyubiquitin. Methods of use the novel IKK2 inhibitor, and composition thereof, for preventing and/or treating inflammation in various diseases involving IKK-NF-?B signaling pathways are also provided.
    Type: Application
    Filed: March 30, 2022
    Publication date: May 23, 2024
    Applicants: The Regents of the University of California, SAN DIEGO STATE UNIVERSITY (SDSU) FOUNDATION, THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS
    Inventors: Gourisankar GHOSH, Sushil MAHATA, Tom HUXFORD