Abstract: Provided herein is a non-invasive biosensing device and method for monitoring opioid response using the non-invasive biosensing device. The non-invasive biosensing device comprises a data collection and communication element. Biosensing extensions are included wherein at least one biosensing extension measures at least one biological function selected from the group consisting of respiratory rate, respiratory strength and duration of respiration. The data collection and communication element receives the measures of biological function and determines indexes based on the measures to form an opioid response index as a summation of the indexes and transmits the opioid response index to a receiver.