Abstract: The present invention relates to a method for producing transplantable oral mucosa tissue by selecting and choosing from oral mucosa biopsy, and to the use thereof as pharmaceutical composition, medicament or transplant or graft material, in particular for urethral reconstruction or cornea implantation. In particular, the invention relates to markers for identifying suitable transplantable oral mucosa tissue for the production of transplantable oral mucosa tissue, in particular for producing an autologous oral mucosa graft or tissue.

Abstract: The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ. The tissue transplant construct (5) comprises (a) a membrane composite (1) comprising at least a first biocompatible, collagen-containing membrane (2) and a second biocompatible, collagen-containing membrane (3), wherein the first membrane (2) and the second membrane (3) are adjacent to each other at their flat sides, and wherein the first membrane (2) is of equine or bovine origin and the second membrane (3) is of animal or human origin and the second membrane (3) is of another origin than the first membrane (2); and (b) one or more layers (4) of mucosa tissue cells on one or both outer flat sides of the membrane composite (1).

Abstract: A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught.

Abstract: A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught.

Abstract: The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ. Here said tissue transplant construct is intended to comprise (a) a biocompatible acellular membrane and (b) microvascular endothelial cells which penetrate the membrane, wherein microvascular structures of microvascular endothelial cells are formed within the membrane.

Abstract: The invention relates to a tissue transplant construct for the reconstruction of a human or animal organ, where the tissue transplant construct comprises: a) a biologically compatible, collagen-containing membrane, and b) one or more layers of organ-specific tissue cells on the membrane, and where the outermost layer of the organ-specific tissue cells is a layer of terminally differentiated organ-specific tissue cells.

Abstract: A process for producing a tissue transplant construct for reconstructing a human or animal organ. The process may include the steps of: (a) isolation and two-dimensional cultivation of organ-specific tissue cells; (b) application of the organ-specific tissue cells to a biocompatible, collagen-containing membrane; and, (c) cultivation of the organ-specific tissue cells on the membrane with biochemical and mechanical stimulation of the organ-specific tissue cells. Tissue transplant constructs and methods for using tissue transplant constructs are also taught.