Patents by Inventor Gouying Zhou

Gouying Zhou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CONSTRUCTION OF ONCOLYTIC HERPES SIMPLEX VIRUSES (oHSV) OBLIGATE VECTOR AND CONSTRUCTS FOR CANCER THERAPY
    Publication number: 20190083555
    Abstract: An obligate oHSV vector comprising modified viral DNA genome is provided. A recombinant oHSV-1 construct comprising the obligate oHSV vector and a heterologous nucleic acid sequence encoding an immunostimulatory and/or immunotherapeutic agent is also provided. Compositions comprising the recombinant oHSV-1 construct can be used for treating cancers.
    Type: Application
    Filed: April 22, 2016
    Publication date: March 21, 2019
    Inventors: Grace Gouying Zhou, Xiaoqing Chen, Xianjie Liu
  • Targeting of herpes simplex virus to specific receptors
    Patent number: 7501126
    Abstract: The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention may be used for targeting cells that express the selected receptor. The ability to selectively target cells renders the HSV particles particularly useful in selectively killing the selected receptor-bearing cells (such as tumor cells), imaging cells bearing the selected receptor, and providing gene replacement therapy to cells bearing the selected receptor.
    Type: Grant
    Filed: October 6, 2003
    Date of Patent: March 10, 2009
    Assignee: The University of Chicago
    Inventors: Bernard Roizman, Gouying Zhou, Guo J. Ye
  • Targeting of herpes simplex virus to specific receptors
    Publication number: 20060068391
    Abstract: The invention relates to engineered Herpes simplex virus (HSV) particles that are targeted to one or more specific receptors. Also, recombinant vectors for producing such HSV particles. By reducing the affinity of HSV for its natural receptor(s) and increasing the affinity for a selected receptor, the HSV particles of the invention may be used for targeting cells that express the selected receptor. The ability to selectively target cells renders the HSV particles particularly useful in selectively killing the selected receptor-bearing cells (such as tumor cells), imaging cells bearing the selected receptor, and providing gene replacement therapy to cells bearing the selected receptor.
    Type: Application
    Filed: October 6, 2003
    Publication date: March 30, 2006
    Applicant: UNIVERSITY OF CHICAGO
    Inventors: Bernard Roizman, Gouying Zhou, Guo Ye