Abstract: A system, comprising a base station and a wireless device, is provided for managing reference signal interference in a wireless communication system allowing device-to-device, D2D, communication. The base station and the wireless device and methods therein are described. The method in the wireless device comprises receiving an indication, from a base station, of downlink transmission resources that are associated with D2D communication in a cell associated with the BS during at least a time period T. The method further comprises determining based on the received indication, downlink reference signals that may be subjected to interference, caused by D2D communication, when performing reference signal measurements during at least the time period T. The method further comprises excluding or reducing 403 the influence of said downlink reference signals when performing reference signal measurements during at least the time period T.