Abstract: The present invention generally relates to a process for manufacturing gel composition of Luliconazole for treatment of vaginal fungal infections cooling 50% quantity of purified water at 4° C.; adding 0.10-0.30% of Carbopol 934, 5-15% of poloxamer 188 and 15-25% of poloxamer 407 slowly under constant stirring and placing at 4° C., until a clear solution is obtained; adding 0.1-0.5% HPMC K100M gradually under stirring and leaving for 24 hours at room temperature; adding 0.5-2% Luliconazole solution slowly under high speed homogenizer; adding 0-0.5% Sodium methyl parabens and 0-1% Sodium propyl parabens solution under constant stirring; adding 0.1-0.5% sodium chloride under stirring; checking and maintaining pH of the obtained solution; and preparing the obtained solution volume to 100% with purified water and stirring for 30 min for manufacturing gel composition of Luliconazole.