Patents by Inventor Govindarajan Padmanaban

Govindarajan Padmanaban has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GRISEOFULVIN AS AN ADJUNCT DRUG FOR THE TREATMENT OF CEREBRAL AND SEVERE MALARIA
    Publication number: 20240009165
    Abstract: Malaria remains a major concern of morbidity and mortality. Despite treating infected individuals with artemisinin-based combination therapies (ACTs), cerebral and severe malaria cause enormous mortality in children and adults. The only treatment option is parenteral administration of artemisinin or quinine with supportive symptomatic therapies. However, the fatality rate remains high despite parasite clearance emphasizing the need of adjunct therapy to prevent malaria mortality. In this invention, heme synthesized in the malaria parasite is shown to be associated with parasite virulence, disease severity and cerebral pathogenesis. Parasite heme enhances the formation of hemozoin—a parasite molecule associated with cerebral and severe malaria. Griseofulvin prevents experimental cerebral malaria (ECM) by inhibiting parasite heme synthesis and hemozoin formation, without affecting parasite growth. Griseofulvin exhibits synergy with arteether—the principal component of ACTs and prevents ECM.
    Type: Application
    Filed: November 15, 2021
    Publication date: January 11, 2024
    Inventors: Viswanathan Arun NAGARAJ, Govindarajan PADMANABAN, Manjunatha Chandana SHETTY, Aditya ANAND, Sourav GHOSH
  • Antimalarial drug containing synergistic combination of curcumin and artemisinin
    Patent number: 7776911
    Abstract: A pharmaceutical composition for the treatment of malaria in mammals is disclosed. The composition comprises of a synergistic combination of curcumin and artemisinin.
    Type: Grant
    Filed: November 7, 2005
    Date of Patent: August 17, 2010
    Assignee: Indian Institute of Science
    Inventors: Govindarajan Padmanaban, Pundi Narasimhan Rangarajan, Vathsala Palakkod Govindan, Dalavaikodihalli Nanjiah Nandakumar, Viswanathan Arun Nagaraj
  • Antimalarial drug containing synergistic combination of curcumin and artemisinin
    Publication number: 20070105945
    Abstract: A pharmaceutical composition for the treatment of malaria in mammals is disclosed. The composition comprises of a synergistic combination of curcumin and artemisinin.
    Type: Application
    Filed: November 7, 2005
    Publication date: May 10, 2007
    Inventors: Govindarajan Padmanaban, Pundi Rangarajan, Vathsala Palakkod Govindan, Dalavaikodihalli Nandakumar, Viswanathan Arun Nagaraj