Patents by Inventor Gowtham THAKKU

Gowtham THAKKU has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AMPLIFICATION ASSAYS USING CRISPR-CAS BASED DETECTION
    Publication number: 20250101500
    Abstract: Described in various embodiments herein are tiled amplification nucleic acid detection systems and uses thereof. In some embodiments, the nucleic acids amplified and detected are cell free DNA (cfDNA).
    Type: Application
    Filed: October 4, 2024
    Publication date: March 27, 2025
    Applicants: The Broad Institute, Inc., Massachusetts Institute of Technology, THE GENERAL HOSPITAL CORPORATION
    Inventors: Deborah HUNG, Gowtham THAKKU, Sharon WONG, James GOMEZ
  • TILED ASSAYS USING CRISPR-CAS BASED DETECTION
    Publication number: 20250043366
    Abstract: Disclosed herein are methods and systems utilizing CRISPR effector systems for assays and diagnostics. Embodiments herein provide tile probes in systems and methods for detection of multiple targets across a given genome or group of genomes, including in circulating nucleic acid samples.
    Type: Application
    Filed: December 13, 2019
    Publication date: February 6, 2025
    Inventors: Gowtham THAKKU, Bwarenaba KAUTU, James GOMEZ, Roby BHATTACHARYYA, Deborah HUNG, Sharon WONG
  • CRISPR SYSTEM HIGH THROUGHPUT DIAGNOSTIC SYSTEMS AND METHODS
    Publication number: 20220228150
    Abstract: High throughput methods utilizing spatially segregated detection systems provide a robust CRISPR-based diagnostic enabling highly sensitive detection of both DNA and RNA target molecules, with applications in multiple scenarios in human health including, for example, viral detection. Kits comprising the systems allow for point-of care applications with high-throughput processing of samples.
    Type: Application
    Filed: March 17, 2021
    Publication date: July 21, 2022
    Inventors: Paul BLAINEY, Pardis SAVEIT, Gowtham THAKKU, Cher ACKERMAN, Cameron MYHRVOLD, Deborah HUNG, Nicole WELCH
  • CRISPR SYSTEM BASED DROPLET DIAGNOSTIC SYSTEMS AND METHODS
    Publication number: 20220073987
    Abstract: RNA targeting proteins are utilized to provide a robust massively multiplexed CRISPR-based diagnostic by detection in droplets with attomolar sensitivity. Detection of both DNA and RNA with comparable levels of sensitivity at nanoliter volumes can differentiate targets from non-targets based on single base pair differences, with applications in multiple scenarios in human health including, for example, viral detection, bacterial strain typing, and sensitive genotyping.
    Type: Application
    Filed: November 14, 2019
    Publication date: March 10, 2022
    Inventors: Catherine Amanda FREIJE, Cameron MYHRVOLD, Hayden METSKY, Pardis SABETI, Gowtham THAKKU, Jared KEHE, Cheri ACKERMAN, Paul BLAINEY, Deborah HUNG