Patents by Inventor Grégoire COURTINE
Grégoire COURTINE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210016093Abstract: The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.Type: ApplicationFiled: September 25, 2020Publication date: January 21, 2021Inventors: Karen MINASSIAN, Fabien WAGNER, Grégoire COURTINE
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Publication number: 20200391030Abstract: The present invention relates to methods and systems for planning and/or providing neuromodulation. An example system comprises a neurostimulator comprising a least one electrode, functional mapping module configured and arranged such that based on stimulation related basic data and stimulation related response data and transfer data a digital characteristic functional map is generated and/or provided, which describes the interrelation between the stimulation related basic data and the stimulation related response data and the transfer data, and analysis module configured and arranged such that the digital characteristic functional map may be analyzed in connection with neurostimulation provided by the neurostimulator such that the provided neurostimulation and its response may be analyzed on the basis of the functional map and that on the basis of this analysis a placement analysis of a placement of the electrode is provided.Type: ApplicationFiled: November 29, 2018Publication date: December 17, 2020Inventors: Marco CAPOGROSSO, Karen MINASSIAN, Fabien WAGNER, Gregoire COURTINE, Miroslav CABAN, Robin BROUNS, Jurriaan BAKKER, Andre KLEIBEUKER, Bert BAKKER, Vincent DELATTRE
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Publication number: 20200384272Abstract: The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activation of the spinal cord of a patient, a healthy spinal cord map storage module (50) for storing at least one reference map (51) describing physiological activation of the spinal cord of at least one healthy subject, an analysis module (42) configured and arranged such that the pathological spinal cord map and the reference map can be compared and/or analyzed automatically such that a deviation map is created, the deviation map describing the difference between the pathological spinal cord map and the reference map, and a compensation module (52) which is configured and arranged to calculate on the basis of the deviation map a neurostimulation protocol for compensating the activation.Type: ApplicationFiled: November 29, 2018Publication date: December 10, 2020Inventors: Flavio RASCHELLA, Silvestro MISERA, Gregoire COURTINE, Tomislav MILEKOVIC, Fabien WAGNER, Marco CAPOGROSSO, Jurriaan BAKKER, Robin BROUNS, Vincent DELATTRE
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Patent number: 10799702Abstract: The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.Type: GrantFiled: May 25, 2018Date of Patent: October 13, 2020Assignee: GTX MEDICAL B.V.Inventors: Karen Minassian, Fabien Wagner, Grégoire Courtine
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Patent number: 10751539Abstract: The present disclosure relates to an active closed-loop medical system comprising at least one implantable medical device, at least one non-implanted component and at least a controller for controlling the implantable medical device, wherein the implantable medical device, the non-implanted component and the controller are connected for data exchange, wherein the implantable medical device, the non-implanted component and the controller forming in the active state a closed-loop system in such that the implantable medical device is controlled by the controller on the basis of the signals exchanged with the non-implanted component.Type: GrantFiled: November 15, 2017Date of Patent: August 25, 2020Assignee: GTX MEDICAL B.V.Inventors: Joachim Von Zitzewitz, Vincent Delattre, Bert Bakker, Grégoire Courtine
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Patent number: 10695555Abstract: A method produces a device adapted to be implanted into the human body for purposes such as neural stimulation, sensing or the like. The method includes: providing a stretchable layer or membrane of an insulating material; forming on the layer or membrane at least one stretchable conductive path; depositing at least one small bolus of a soft and conductive paste or material onto pre-defined areas or portions of the at least one conductive path, and inserting a first end portion of a conductive element 71 into the at least one bolus of soft conductive paste or material. A second end portion of the conductive element opposite to the first end portion is not inserted into the at least one bolus.Type: GrantFiled: January 8, 2016Date of Patent: June 30, 2020Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Ivan Rusev Minev, Arthur Hirsch, Pavel Musienko, Grégoire Courtine, Stephanie P. Lacour
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Patent number: 10668280Abstract: Methods and systems are provided for triggering electrical stimulation of a spinal cord during execution of a motor event. In one example, a method comprises monitoring motor cortex activity while execution of a desired motor movement is attempted during a first mode where one or more nerve fibers are not stimulated, and during a second mode where the one or more nerve fibers are stimulated. Delivery timing of electrical stimulation may be closed-loop controlled based on current motor cortex activity and the motor cortex activity recorded previously during both the first and second modes.Type: GrantFiled: November 1, 2016Date of Patent: June 2, 2020Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Tomislav Milekovic, Marco Capogrosso, Gregoire Courtine, Eduardo Martin Moraud, Fabien Wagner, Jerome Gandar
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Patent number: 10632105Abstract: The invention relates to the selective targeting of specific ?2 adrenergic receptor subtypes for facilitating and also restoring standing and walking in a subject affected by spinal cord disorders, in particular spinal cord injury. In particular, the improvement of locomotion by targeting specific receptor subtypes can be achieved by stimulation of the ?2c receptor subtype using an ?2c specific agonist or by blocking the ?2a receptor subtype using ?2a antagonists. A combination of an ?2c agonist and an ?2a antagonist is also provided for a synergistic effect. Alternatively, a large ?2 agonist can be used in combination with an ?2a antagonist to achieve specific stimulation of the ?2c receptor. Pharmaceutical compositions, kit-of-parts and therapeutic systems comprising said agonists/antagonists as active agents are objects of the present invention.Type: GrantFiled: June 27, 2014Date of Patent: April 28, 2020Assignee: ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE (EPFL)Inventors: Grégoire Courtine, Quentin Barraud, Pavel Musienko
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Publication number: 20200086116Abstract: The present invention refers to a system for stimulation of the spinal cord for the rehabilitation of motor function in subjects with spinal cord injury or other motor disorders. Said system comprises a programmable implantable pulse generator (IPG), operatively connected to deliver current pulses to one or more multi-electrode arrays, wherein said IPG is adapted to deliver to said multi-electrode array a stimulation characterized by a frequency comprised between 20 and 1200 Hz and an amplitude comprised between 0.1 motor threshold amplitude and 1.5 motor threshold amplitude. The use of such system for facilitating locomotor functions or upper limb movements in a subject with neuromotor impairments is also within the scope of the invention.Type: ApplicationFiled: December 19, 2017Publication date: March 19, 2020Inventors: Emanuele FORMENTO, Marco CAPOGROSSO, Silvestro MICERA, Grégoire COURTINE, Karen MINASSIAN
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Publication number: 20190366077Abstract: The present invention relates to an electrode array for neuromodulation, comprising a first electrode section with more than two electrodes being arranged parallel and densely packed in the first electrode section, further comprising a second electrode section with more electrodes than in the first electrode section, the electrodes in the second electrode section being arranged symmetrically with respect to the longitudinal axis and transversal offset to each other. Furthermore, the present invention relates to a lead paddle and a neuromodulation system.Type: ApplicationFiled: May 30, 2019Publication date: December 5, 2019Inventors: Marco Capogrosso, Fabien Wagner, Gregoire Courtine, Vincent Delattre, Karen Minassian, Bert Bakker, Jocelyne Bloch, Nathan Greiner, Damien Ganty, Sjaak Deckers, Edoardo Paoles
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Publication number: 20190344075Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: ApplicationFiled: July 10, 2019Publication date: November 14, 2019Inventors: Jocelyne BLOCH, Grégoire COURTINE, Nikolaus WENGER, Silvestro MICERA, Marco CAPOGROSSO
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Patent number: 10406056Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.Type: GrantFiled: August 3, 2017Date of Patent: September 10, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Grégoire Courtine, Silvestro Micera, Joachim Von Zitzewitz
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Publication number: 20190269917Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.Type: ApplicationFiled: March 4, 2019Publication date: September 5, 2019Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Patent number: 10391309Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: December 21, 2016Date of Patent: August 27, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Patent number: 10391015Abstract: It is disclosed an apparatus for restoring voluntary control of locomotion in a subject suffering from a neuromotor impairment comprising a multidirectional trunk support system and a device for epidural electrical stimulation. The robotic interface is capable of evaluating, enabling and training motor pattern generation and balance across a variety of natural walking behaviors in subjects with neuromotor impairments. Optionally, pharmacological cocktails can be administered to enhance rehabilitation results. It is also disclosed a method for the evaluation, enablement and training of a subject suffering from neuromotor impairments by combining robotically assisted evaluation tools with sophisticated neurobiomechanical and statistical analyzes. A method for the rehabilitation (by this term also comprising restoring voluntary control of locomotion) of a subject suffering from a neuromotor impairment in particular partial or total paralysis of limbs, is also disclosed.Type: GrantFiled: August 3, 2017Date of Patent: August 27, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Grégoire Courtine, Silvestro Micera, Joachim Von Zitzewitz
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Patent number: 10279177Abstract: The present disclosure refers to systems for electrical neurostimulation of a spinal cord of a subject in need of nervous system function support. In one example, a system comprises a signal processing device configured to receive signals from the subject and operate signal-processing algorithms to elaborate stimulation parameter settings; one or more multi-electrode arrays suitable to cover a portion of the spinal cord of the subject; and an Implantable Pulse Generator (IPG) configured to receive the stimulation parameter settings from the signal processing device and simultaneously deliver independent current or voltage pulses to the one or more multiple electrode arrays, wherein the independent current or voltage pulses provide multipolar spatiotemporal stimulation of spinal circuits and/or dorsal roots. Such system advantageously enables effective control of nervous system functions in the subject by stimulating the spinal cord, such as the dorsal roots of the spinal cord, with spatiotemporal selectivity.Type: GrantFiled: August 4, 2017Date of Patent: May 7, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Jocelyne Bloch, Grégoire Courtine, Nikolaus Wenger, Silvestro Micera, Marco Capogrosso
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Patent number: 10279167Abstract: The present disclosure provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising electrodes for applying to a subject neuromodulation with adjustable stimulation parameters, the electrodes being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with the electrodes said and providing the electrodes with new stimulation parameters, with minimum delay. The system of the disclosure improves consistency of walking in a subject with a neuromotor impairment.Type: GrantFiled: September 27, 2017Date of Patent: May 7, 2019Assignee: Ecole Polytechnique Federale De Lausanne (EPFL)Inventors: Grégoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Patent number: 10265525Abstract: The present invention provides a closed-loop system for real-time control of epidural and/or subdural electrical stimulation comprising: means for applying to a subject neuromodulation with adjustable stimulation parameters, said means being operatively connected with a real-time monitoring component comprising sensors continuously acquiring feedback signals from said subject, said signals being neural signals and/or signals providing features of motion of said subject, said system being operatively connected with a signal processing device receiving said feedback signals and operating real-time automatic control algorithms, said signal processing device being operatively connected with said means and providing said means with new stimulation parameters, with minimum delay. The system of the invention improves consistency of walking in a subject with a neuromotor impairment.Type: GrantFiled: October 29, 2014Date of Patent: April 23, 2019Assignee: ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)Inventors: Gregoire Courtine, Nikolaus Wenger, Eduardo Martin Moraud, Silvestro Micera, Marco Bonizzato
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Publication number: 20190001138Abstract: The present disclosure relates to a system for neuromodulation and/or neurostimulation, for the treatment of a subject. The system comprises a stimulation controller, a stimulation pattern storage means including stimulation data connected to the stimulation controller, an electrical stimulation device and electrical interface between the electrical stimulation device and the subject, the electrical interface being connectable with a bio-interface of the nervous system of the subject. The stimulation data are pre-programmed patterns comprising spatial and temporal components, The stimulation controller sends configuration signals on the basis of the stimulation data to the electrical stimulation device such that via the electrical interface electrical stimulation is provided to the bio-interface, wherein the electrical stimulation provided is characterized by stimulation parameters that vary over time in a pre-programmed manner.Type: ApplicationFiled: May 25, 2018Publication date: January 3, 2019Inventors: Karen MINASSIAN, Fabien WAGNER, Grégoire COURTINE
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Patent number: D907206Type: GrantFiled: November 29, 2018Date of Patent: January 5, 2021Assignee: GTX MEDICAL B.V.Inventors: Damien Ganty, Egbertus Bakker, Jacobus Deckers, Edoardo Paoles, Vincent Delattre, Jocelyne Bloch, Grégoire Courtine, Marco Capogrosso, Fabien Wagner, Nathan Greiner, Karen Minassian