Abstract: An end effector is disclosed that is configured for connection to a robotic unit used to manipulate a door of a vehicle (e.g., during vehicle painting). The end effector includes a base plate; a sensor that is supported by the base plate; and a piston that is configured for engagement with the door. The piston is operatively connected to an interrupter such that movement (displacement) of the piston causes corresponding movement (displacement) of the interrupter between a first position, in which the interrupter is positioned in alignment with a signal transmitted across the sensor to interfere with the signal and thereby interrupt circuit completion, and a second position, in which the interrupter is out of alignment with the signal transmitted across the sensor to permit circuit completion and thereby inform the robotic unit that the door is present and engaged with the end effector.

Abstract: The present invention relates to a PAK-1 and/or PAK-2 inhibitor for use in the treatment of NLRP3 inflammasome mediated IL-1beta dependent disorders in a subject in need thereof. Inventors invalidated PAK-1 and/or PAK-2 in BMDM by transfecting siRNA targeting either PAK-1 and/or PAK-2 (PAK-3 is predominantly expressed in the brain). After 72 hours of siRNA expression, cells were stimulated by LPS and the CNF1 toxin for 8 hours. They observed that cells invalidated for PAK-1 had a reduced Caspase-1 activation compared to the control cells or cells invalidated for PAK-2. Similar results were observed when the IL-1? maturation was monitored. Confirming this data, the use of PAK-1 inhibitors (IPA-3 and FRAX597) were sufficient to block the IL-1? maturation observed in macrophages treated with LPS and CNF1 as well as Caspase-1 activation measured using FAM-FLICA.

Abstract: An end effector is disclosed that is configured for connection to a robotic unit used to manipulate a door of a vehicle (e.g., during vehicle painting). The end effector includes a base plate; a sensor that is supported by the base plate; and a piston that is configured for engagement with the door. The piston is operatively connected to an interrupter such that movement (displacement) of the piston causes corresponding movement (displacement) of the interrupter between a first position, in which the interrupter is positioned in alignment with a signal transmitted across the sensor to interfere with the signal and thereby interrupt circuit completion, and a second position, in which the interrupter is out of alignment with the signal transmitted across the sensor to permit circuit completion and thereby inform the robotic unit that the door is present and engaged with the end effector.

Abstract: A Disposable Underarm Perspiration Pad that comprises a light-weight moisture wicking and absorptive material that is worn as a perspiration shield between a person's underarm and the next level of outer garment is presented. The inventive device is configured to enable attachment to the upper bicep area of the arm and concealment under the outer garment while at the same time providing wearing comfortability to the user. Attachment to the upper bicep area of the arm can be accomplished with a fixed or adjustable member.

Abstract: The invention relates to a Rho GTPase activator, such as namely the cytotoxic necrotizing factor 1 (CNF1), for use in preventing and/or treating infections by a pathogen in a patient in need thereof. The invention also relates to a Rho GTPase activator, such as CNF1, for use in preventing and/or treating pathologies associated with an infection by a pathogen in a patient in need thereof. For instance, the invention relates to a Rho GTPase activator for use in treating infections by bacteria in a patient in need thereof and also relates to a Rho GTPase activator for use in reducing or eliminating bacteremia in a patient in need thereof.

Abstract: A Disposable Underarm Perspiration Pad that comprises a light-weight moisture wicking and absorptive material that is worn as a perspiration shield between a person's underarm (armpit) and the next level of outer garment. The Disposable Underarm Perspiration Pad is fashioned to allow attachment to the upper bicep area of the arm and concealment under the outer garment while at the same time providing wearing comfortability to the user. The wearer of the Disposable Underarm Perspiration Pad will have the pleasure of knowing that their upper body outer garment, next to the body, will be shielded from underarm perspiration staining.

Abstract: An Upper-Body Undergarment (undershirt garment) that can be worn directly on top of the skin but beneath the next layer of garment as outer garment protection from upper body perspiration stains. The said undergarment is fashioned to allow ventilation and concealment and is ideal for wearing under outer garments such as shirts, T-shirts, coats, jackets, sweaters and the likes, especially in climates that are hot and the need to wear less clothing becomes important.

Abstract: A cruise chip having a plurality of decks, certain of the decks having a plurality of staterooms therealong, the plurality of spaced staterooms extending along one of the decks and a second plurality of spaced staterooms extending along another of the decks directly above the other of said decks, and a single central double height corridor extending inboard of the ship, each of the plurality of spaced staterooms and shared entryways coming from the single central corridor and leading into a pair of side by side staterooms, the corridor terminating in a transparent glass window spanning one the decks to the other of decks.

Abstract: A cruise chip having a plurality of decks, certain of the decks having a plurality of staterooms therealong, the plurality of spaced staterooms extending along one of the decks and a second plurality of spaced staterooms extending along another of the decks directly above the other of said decks, and a single central double height corridor extending inboard of the ship, each of the plurality of spaced staterooms and shared entryways coming from the single central corridor and leading into a pair of side by side staterooms, the corridor terminating in a transparent glass window spanning one the decks to the other of decks.