Patents by Inventor Grace A. McClure

Grace A. McClure has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tyrissamycin antibiotic
    Patent number: 7256024
    Abstract: A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
    Type: Grant
    Filed: November 18, 2004
    Date of Patent: August 14, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jingfang Q. Cutrone, Lyndon M. Foster, Kimberly D. Krampitz, Stephen W. Mamber, Grace A. McClure, Todd C. Peterson, Lisa C. Rupar, Katie A. Thompson
  • MICROBIAL TRANSFORMATION METHOD FOR THE PREPARATION OF AN EPOTHILONE
    Publication number: 20070184533
    Abstract: A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
    Type: Application
    Filed: April 6, 2007
    Publication date: August 9, 2007
    Inventors: Wenying Li, James Matson, Xiaohua Huang, Kin Lam, Grace McClure
  • Microbial transformation method for the preparation of an epothilone
    Patent number: 7244594
    Abstract: A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
    Type: Grant
    Filed: March 23, 2004
    Date of Patent: July 17, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wenying Li, James A. Matson, Xiaohua Huang, Kin Sing Lam, Grace A. McClure
  • Tyrissamycin antibiotic
    Publication number: 20050064568
    Abstract: A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
    Type: Application
    Filed: November 18, 2004
    Publication date: March 24, 2005
    Inventors: Jingfang Cutrone, Lyndon Foster, Kimberly Krampitz, Stephen Mamber, Grace McClure, Todd Peterson, Lisa Rupar, Katie Thompson
  • Microbial transformation method for the preparation of an epothilone
    Publication number: 20040176429
    Abstract: A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
    Type: Application
    Filed: March 23, 2004
    Publication date: September 9, 2004
    Inventors: Wenying Li, James A. Matson, Xiaohua Huang, Kin Sing Lam, Grace A. McClure
  • Microbial transformation method for the preparation of an epothilone
    Patent number: 6780620
    Abstract: A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said alkyl group to a hydroxyalkyl group, and effecting said hydroxylation.
    Type: Grant
    Filed: December 21, 1999
    Date of Patent: August 24, 2004
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wenying Li, James A. Matson, Xiaohua Huang, Kin Sing Lam, Grace A. McClure
  • Tyrissamycin antibiotic
    Publication number: 20020119145
    Abstract: A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
    Type: Application
    Filed: October 1, 2001
    Publication date: August 29, 2002
    Inventors: Jingfang Cutrone, Lyndon M. Foster, Kimberly Krampitz, Stephen W. Mamber, Grace McClure, Todd C. Peterson, Lisa C. Rupar, Katie A. Thompson
  • Tyrissamycin antibiotic
    Patent number: 6328961
    Abstract: A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Streptomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, particularly against gram-positive bacteria.
    Type: Grant
    Filed: August 20, 1999
    Date of Patent: December 11, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jingfang Cutrone, Lyndon M. Foster, Kimberly Krampitz, Stephen W. Mamber, Grace McClure, Todd C. Peterson, Lisa C. Rupar, Katie A. Thompson