Abstract: Provided are methods and compositions from reprogramming human glial cells into human neurons. The reprogramming is achieved using combinations of compounds that can modify signaling via Transforming growth factor beta (TGF-?), Bone morphogenetic protein (BMP), glycogen synthase kinase 3 (GSK-3), and ?-secretase/Notch pathways. The reprogramming is demonstrated using groups of three or four compounds that are chosen from the group thiazovivin, LDN193189, SB431542, TTNPB, CHIR99021, DAPT, VPA, SAG, purmorphamine. Reprogramming is demonstrated using the group of LDN193189/CHIR99021/DAPT, the group of B431542/CHIR99021/DAPT, the group of LDN193189/DAPT/SB431542, the group of LDN193189/CHIR99021/SB431542, a three drug combination of SB431542/CHIR99021/DAPT. Reprogramming using functional analogs of the compounds is also provided, as are pharmaceutical formulations that contain the drug combinations.

Abstract: The present disclosure provides human tumor necrosis factor alpha antibody glucocorticoid receptor agonist conjugates and methods of using the conjugates for the treatment of autoimmune and inflammatory diseases.

Abstract: The present disclosure relates to antibodies that specifically bind soluble and membrane forms of human TNF?, compositions comprising such TNF? antibodies, and methods of using such TNF? antibodies and compositions.

Abstract: One exemplary embodiment can be a separation system. The separation system can include an adsorption zone, a rotary valve, a transition zone, and one or more pipes. Usually, the transition zone includes one or more lines communicating the rotary valve with the adsorption zone. The rotary valve alternatively may distribute an input of a feed or a desorbent to the adsorption zone or alternatively can receive an output of a raffinate or an extract from the adsorption zone in a line, and a remnant may remain in the line from a previous input or output. One or more pipes outside the transition zone communicating with the rotary valve can form at least one pipe volume receiving an input for dislodging a remnant or for receiving a remnant from the line. The remnant may be different from the input or output.

Abstract: One exemplary embodiment can be a separation system. The separation system can include an adsorption zone, a rotary valve, a transition zone, and one or more pipes. Usually, the transition zone includes one or more lines communicating the rotary valve with the adsorption zone. The rotary valve alternatively may distribute an input of a feed or a desorbent to the adsorption zone or alternatively can receive an output of a raffinate or an extract from the adsorption zone in a line, and a remnant may remain in the line from a previous input or output. One or more pipes outside the transition zone communicating with the rotary valve can form at least one pipe volume receiving an input for dislodging a remnant or for receiving a remnant from the line. The remnant may be different from the input or output.

Abstract: One exemplary embodiment can be a separation system. The separation system can include an adsorption zone, a rotary valve, a transition zone, and one or more pipes. Usually, the transition zone includes one or more lines communicating the rotary valve with the adsorption zone. The rotary valve alternatively may distribute an input of a feed or a desorbent to the adsorption zone or alternatively can receive an output of a raffinate or an extract from the adsorption zone in a line, and a remnant may remain in the line from a previous input or output. One or more pipes outside the transition zone communicating with the rotary valve can form at least one pipe volume receiving an input for dislodging a remnant or for receiving a remnant from the line. The remnant may be different from the input or output.

Abstract: One exemplary embodiment can be a separation system. The separation system can include an adsorption zone, a rotary valve, a transition zone, and one or more pipes. Usually, the transition zone includes one or more lines communicating the rotary valve with the adsorption zone. The rotary valve alternatively may distribute an input of a feed or a desorbent to the adsorption zone or alternatively can receive an output of a raffinate or an extract from the adsorption zone in a line, and a remnant may remain in the line from a previous input or output. One or more pipes outside the transition zone communicating with the rotary valve can form at least one pipe volume receiving an input for dislodging a remnant or for receiving a remnant from the line. The remnant may be different from the input or output.