Abstract: The present disclosure provides a resective epilepsy surgery simulator that incorporates biocompatible, dissectible materials as well as the surgical anatomy cues that would support the acquisition of the required technical skill set to ultimately broach the gap in surgical care for patients living with epilepsy. The simulator is produced by imaging a patient's brain and performing computer aided design to select the gray and white matter layers of the brain, the brain blood vessels, and the skull based on the imaging of the patient's brain and storing them in computer aided design files. These files are converted into a format readable by a 3D printer and programming the 3D printer to print the patient's brain simulator from the computer aided design files with the 3D printer containing multiple print-heads that extrude liquid polymer one multi-material layer at a time to produce a simulator of the patient's skull and brain.