Patents by Inventor Grace Tharmini Tharmarajah

Grace Tharmini Tharmarajah has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for transfecting resistant cell types
    Patent number: 11572575
    Abstract: A transfection reagent composition comprising: 30-60 MOL. % of a cationic lipid, or a pharmaceutical acceptable salt thereof; 10-60 MOL % of a structural lipid; 10-20 MOL % of a triglyceride; and 0.1 to about 10 MOL. % of a stabilizing agent, is provided. The transfection agent is effective in transfecting cells, particularly neurons, with siRNA, mRNA and plasmid nucleic acid, Sand maintaining viability of the cells as well as activity of the delivered nucleic acid.
    Type: Grant
    Filed: December 19, 2017
    Date of Patent: February 7, 2023
    Assignee: Precision NanoSystems ULC
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
  • Compositions for Transfecting Resistant Cell Types
    Publication number: 20210284998
    Abstract: A transfection reagent composition comprising: 30-60 MOL % of an cationic lipid, or pharmaceutical acceptable salt thereof; 10-60 MOL % structural lipid; a sterol and 0.1 to about 10 MOL % of a stabilizing agent is provided. The reagent is particularly adapted for neuron and related cell types. A method of manufacturing LNP including nucleic acid for selective uptake into either neurons or astrocytes or neural progenitor cells is also provided.
    Type: Application
    Filed: October 2, 2017
    Publication date: September 16, 2021
    Applicant: Precision NanoSystems Inc.
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg
  • Compositions for Transfecting Resistant Cell Types
    Publication number: 20190292566
    Abstract: A transfection reagent composition comprising: 30-60 MOL. % of a cationic lipid, or a pharmaceutical acceptable salt thereof; 10-60 MOL % of a structural lipid; 10-20 MOL % of a triglyceride; and 0.1 to about 10 MOL. % of a stabilizing agent, is provided. The transfection agent is effective in transfecting cells, particularly neurons, with siRNA, mRNA and plasmid nucleic acid, Sand maintaining viability of the cells as well as activity of the delivered nucleic acid.
    Type: Application
    Filed: December 19, 2017
    Publication date: September 26, 2019
    Applicant: Precision NanoSystems Inc.
    Inventors: Anitha Thomas, Rebecca Anne Grace De Souza, Eric Ouellet, Grace Tharmini Tharmarajah, Jagbir Singh, Shyam Madhusudan Garg