Patents by Inventor Grace Y. OLINGER

Grace Y. OLINGER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PDE5 compositions and methods for immunotherapy
    Patent number: 11666642
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Grant
    Filed: February 1, 2022
    Date of Patent: June 6, 2023
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • DHFR tunable protein regulation
    Patent number: 11629340
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Grant
    Filed: September 2, 2019
    Date of Patent: April 18, 2023
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Dan Jun Li, Dexue Sun, Byron Delabarre, Vijaya Balakrishnan, Brian Dolinski, Mara Christine Inniss, Grace Y. Olinger
  • PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20230074330
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: February 1, 2022
    Publication date: March 9, 2023
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • CA2 COMPOSITIONS AND METHODS FOR TUNABLE REGULATION
    Publication number: 20230026259
    Abstract: The present disclosure provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities. In particular, the present application is directed to fusion proteins comprising a fragment of human human carbonic anhydrase 2 and a chimeric antigen receptor (CAR). The activity of the destabilizing domain can be regulated by externally administered agents.
    Type: Application
    Filed: March 6, 2020
    Publication date: January 26, 2023
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine Inniss, Dexue SUN, Elizabeth Jane WEISMAN, Grace Y. Olinger, Scott Francis HELLER, Jennifer Leah GORI, Michelle Lynn OLS, Kutlu Goksu ELPEK, Tucker Read EZELL, Michael SCHEBESTA, Michelle Lois FLEURY, Dhruv Kam SETHI
  • PDE5 DERIVED REGULATORY CONSTRUCTS AND METHODS OF USE IN IMMUNOTHERAPY
    Publication number: 20220403001
    Abstract: The present disclosure relates to tunable biocircuit systems for the development of controlled and/or regulated therapeutic systems. In particular, regulatable biocircuits containing destabilizing domains (DD) derived from mutant human cGMP-specific phosphodiesterase type 5 (PDE5) are disclosed. Especially, the present disclosure provides an effector module. Such effector module may include (a) a stimulus response element (SRE), wherein the SRE is a DD, said DD comprising at least one mutation relative to cGMP-specific 3?,5?-cyclic phosphodiesterase (hPDE5; SEQ ID NO: 1) and (b) at least one payload, which is attached, appended or associated with said SRE. The SRE may be responsive to one or more stimuli.
    Type: Application
    Filed: June 12, 2019
    Publication date: December 22, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine INNISS, Dexue SUN, Dan Jun LI, Grace Y. OLINGER, Scott Francis HELLER, Jennifer Leah GORI, Byron DELABARRE
  • COMPOSITIONS AND METHODS FOR DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20220348937
    Abstract: The present disclosure is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: September 4, 2020
    Publication date: November 3, 2022
    Inventors: Mara Christine Inniss, Janine Elizabeth Elya, Grace Y. Olinger, Vipin Suri
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20220213449
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: December 28, 2021
    Publication date: July 7, 2022
    Applicant: Obsidian Therapeutics, Inc.
    Inventors: Vipin SURI, Dan Jun LI, Dexue SUN, Byron DELABARRE, Vijaya BALAKRISHNAN, Brian DOLINSKI, Mara Christine INNISS, Grace Y. OLINGER
  • COMPOSITIONS AND METHODS FOR TUNABLE REGULATION OF CAS NUCLEASES
    Publication number: 20220170011
    Abstract: The present disclosure provides compositions and methods related to regulatable Cas systems. Such systems provide for ligand-dependent, modular and tunable Cas protein expression and activity.
    Type: Application
    Filed: December 10, 2021
    Publication date: June 2, 2022
    Applicant: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Mara Christine INNISS, Grace Y. OLINGER, Samantha FLEURY, Jennifer Leah GORI
  • PDE5 compositions and methods for immunotherapy
    Patent number: 11241485
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Grant
    Filed: June 12, 2018
    Date of Patent: February 8, 2022
    Assignee: OBSIDIAN THERAPEUTICS, INC.
    Inventors: Vipin Suri, Byron Delabarre, Michael N. Gladstone, Celeste Richardson, Brian Dolinski, Abhishek Kulkarni, Mara Christine Inniss, Dexue Sun, Dan Jun Li, Grace Y. Olinger, Scott Francis Heller
  • DHFR TUNABLE PROTEIN REGULATION
    Publication number: 20200172879
    Abstract: The present invention is related to compositions and methods for the regulated and controlled expression of proteins.
    Type: Application
    Filed: September 2, 2019
    Publication date: June 4, 2020
    Inventors: Vipin SURI, Dan Jun LI, Dexue SUN, Byron DELABARRE, Vijaya BALAKRISHNAN, Brian DOLINSKI, Mara Christine INNISS, Grace Y. OLINGER
  • PDE5 COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY
    Publication number: 20200101142
    Abstract: The present invention relates to compositions and methods for the regulated and controlled expression of proteins. Methods for inducing anti-cancer immune responses in a subject are also provided.
    Type: Application
    Filed: June 12, 2018
    Publication date: April 2, 2020
    Inventors: Vipin SURI, Byron DELABARRE, Michael N. GLADSTONE, Celeste RICHARDSON, Brian DOLINSKI, Abhishek KULKARNI, Mara Christine INNISS, Dexue SUN, Dan Jun LI, Grace Y. OLINGER, Scott Francis HELLER