Abstract: The present disclosure provides systems and methods for targeted indirect, synergistic hybridization capture of a template for amplification and analysis of target sequences. The captured templates can be further treated with bisulfite or other methylation reagents to study the methylation pattern of the nucleic acid molecules of the template.

Abstract: The present disclosure provides targeted hybridization and/or proximity ligation of a probe for amplification and analysis of target sequences. The hybridization of the probe to the target sequences can be direct or through indirect association.

Abstract: Embodiments of the invention are directed to systems, methods and computer program products for interpolating impedance data associated with an electronic device. The present invention enables faster electronic device impedance analysis which in turn will have an impact on memory allocation associated with a computing system that controls the electronic device. An exemplary method comprises receiving complex impedance data; converting the complex impedance data to polar impedance data, wherein the polar impedance data defines a Kennelly circle; normalizing the polar impedance data based on at least one parameter associated with the Kennelly circle; and interpolating the polar impedance data for a selected frequency.

Abstract: A piston assembly and a method of making the same. Exemplary piston assemblies may include a piston crown having a ring belt portion defining a cooling gallery, and a strut extending away from the ring belt portion to define a wrist pin bore. The piston may further include a piston skirt assembly secured to the strut. The piston skirt assembly may include two separate portions that each have a closure plate formed integrally with the portion, with the closure plate generally enclosing the cooling gallery. Exemplary methods of assembling a piston may include providing a piston crown having a ring belt portion defining a cooling gallery and a strut extending away from the ring belt portion to define a wrist pin bore. The methods may further include forming a piston skirt assembly having two portions having a closure plate integrally formed therewith, and securing the skirt to the crown.

Abstract: An exemplary piston assembly and method of making the same are disclosed. A piston assembly may include a piston crown and piston skirt. The crown may include a ring belt portion defining at least in part a cooling gallery, as well as radially inner and outer crown mating surfaces. The skirt may be received in a central opening of the crown such that the crown and skirt cooperate to form an upper combustion bowl surface. The skirt also may include radially inner and outer skirt mating surfaces that are abutted with the inner and outer crown mating surfaces, respectively, such that the cooling gallery is generally enclosed by the skirt.

Abstract: A piston assembly and a method of making the same. Exemplary piston assemblies may include a piston crown having a ring belt portion defining a cooling gallery, and a strut extending away from the ring belt portion to define a wrist pin bore. The piston may further include a piston skirt assembly secured to the strut. The piston skirt assembly may include two separate portions that each have a closure plate formed integrally with the portion, with the closure plate generally enclosing the cooling gallery. Exemplary methods of assembling a piston may include providing a piston crown having a ring belt portion defining a cooling gallery and a strut extending away from the ring belt portion to define a wrist pin bore. The methods may further include forming a piston skirt assembly having two portions having a closure plate integrally formed therewith, and securing the skirt to the crown.

Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Abstract: A piston for a combustion engine has a basic element and a ring carrier element held on the basic element with a top land all around its circumference and a ring belt all around its circumference. The ring carrier element grips around the basic element at least partially and is held on the basic element by a press fit.

Abstract: The present invention relates to a piston (10, 110) for a combustion engine having a basic element (11, 111) and a ring carrier element (12, 112) held on the basic element (11, 111) with a top land (25, 125) all around its circumference and ring belt (26, 126) all around its circumference. It is provided in accordance with the invention that the ring carrier element (12, 112) grips around the basic element (11, 111) at least partially and is held on the basic element (11, 111) by means of a press fit.

Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.

Abstract: The present invention provides isolated nucleic acid and amino acid sequences of sweet taste receptors, the receptors comprising consisting of a monomer or homodimer of a T1R3 G-protein coupled receptor polypeptide, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of sweet and amino acid taste receptors.