Abstract: Disclosed is a pharmaceutical composition comprising oncolytic herpes simplex virus expressing IL12 and PD-1 antibody for treatment of cancer through systemic administration.

Abstract: Provided is a recombinant virus comprising a fragment of exogenous polynucleotides encoding suppressor of cytokine signaling 4 (SOCS4) or a functional fragment thereof, wherein the recombinant vims expresses SOCS4 or the functional fragment once replication in a cell. Also provided are use of a recombinant oncolytic virus for preparation of therapeutic drugs of cancer and side effects of virus infection.

Abstract: Disclosed is a method for prophylaxis or treatment of infection of a virus, or for modulating innate immunity, in a subject comprising administering to the subject a therapeutically effective amount of a PUM1 inhibitor. A pharmaceutical composition comprising the PUM1 inhibitor is also disclosed.

Abstract: Disclosed is a method for prophylaxis or treatment of infection of a virus, or for modulating innate immunity, in a subject comprising administering to the subject a therapeutically effective amount of a PUM1 inhibitor. A pharmaceutical composition comprising the PUM1 inhibitor is also disclosed.

Abstract: An interleaver circuit architectures, which utilizes the relationship between intra-row elements in a matrix, in order to simplify the MOD computations necessary in an interleaver. The interleaver calculates a subset of results, stores those results, performs operations on the stored results in order to obtain new results, then updates at least some of the old results with the new results for the next column operation. The interleaver address is then calculated row by row. By storing only a subset of the results and replacing old results with new results, the interleaver can calculate the interleaver address “on the fly” in one clock cycle with very little delay. The interleaver may also require less power and smaller substrate surface area.

Abstract: An interleaver circuit architectures which utilizes the relationship between intra-row elements in a matrix, in order to simplify the MOD computations necessary in an interleaver. The interleaver calculates a subset of results, stores those results, performs operations on the stored results in order to obtain new results, then updates at least some of the old results with the new results for the next column operation. The interleaver address is then calculated row by row. By storing only a subset of the results and replacing old results with new results, the interleaver can calculate the interleaver address “on the fly” in one clock cycle with very little delay. The interleaver may also require less power and smaller substrate surface area.