Patents by Inventor Graciela Andrei

Graciela Andrei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Prodrugs of nucleoside phosphonates
    Patent number: 11040047
    Abstract: The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: June 22, 2021
    Assignee: Katholieke Universiteit Leuven
    Inventors: Graciela Andrei, Steven De Jonghe, Elisabetta Groaz, Piet Herdewijn, Min Luo, Dominique Schols, Robert Snoeck
  • NOVEL PRODRUGS OF NUCLEOSIDE PHOSPHONATES
    Publication number: 20200016180
    Abstract: The present invention relates to novel phosphonoamidate prodrugs. The invention also relates to the use of these novel phosphonate-modified nucleosides to treat or prevent viral infections and their use to manufacture a medicine to treat or prevent viral infections, particularly infections with viruses such as the herpes simplex virus 1, herpes simplex virus 2, human cytomegalovirus, varicella zoster virus, vaccinia virus and adenovirus.
    Type: Application
    Filed: March 21, 2018
    Publication date: January 16, 2020
    Inventors: Graciela Andrei, Steven De Jonghe, Elisabetta Groaz, Piet Herdewijn, Min Luo, Dominique Schols, Robert Snoeck
  • NOVEL ANTIVIRAL ACYCLIC NUCLEOSIDE PHOSPHONATES
    Publication number: 20130231307
    Abstract: Compounds of formula (I) wherein A represents a nucleobase or a derivative thereof, n is equal to 0 or 1 and R?, R? are carbonic chain, and R10 is hydrogen or a carbonic chain for their use as antiviral agents.
    Type: Application
    Filed: June 1, 2011
    Publication date: September 5, 2013
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, KATHOLIEKE UNIVERSITEIT LEUVEN-K.U. LEUVEN R&D, UNIVERSITE DE ORLEANS
    Inventors: Luigi A. Agrofoglio, Vincent Roy, Hugo Pradere, Jan Balzarini, Robert Snoeck, Graciela Andrei
  • Azacytosine derivatives useful as antiviral agents
    Patent number: 8153787
    Abstract: The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising such 5-azacytosine derivatives as active ingredients in combination with pharmaceutically acceptable carriers, which are useful for the treatment of subjects suffering from viral infections.
    Type: Grant
    Filed: December 8, 2006
    Date of Patent: April 10, 2012
    Assignees: K.U. Leuven Research & Development, Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic
    Inventors: Antonin Holy, Marcela Krecmerova, Alois Piskala, Graciela Andrei, Robert Snoeck, Erik De Clercq, Johan Neyts, Lieve Naesens
  • Azacytosine Derivatives Useful as Antiviral Agents
    Publication number: 20090005346
    Abstract: The present invention provides 5-azacytosine derivatives with antiviral activity, specifically having viral replication inhibiting properties, more particularly in DNA viruses such as pox-, papilloma- and herpes viruses in humans. The invention also provides pharmaceutical compositions comprising such 5-azacytosine derivatives as active ingredients in combination with pharmaceutically acceptable carriers, which are useful for the treatment of subjects suffering from viral infections.
    Type: Application
    Filed: December 8, 2006
    Publication date: January 1, 2009
    Applicants: K.U.Leuven Research & Development, Institute of Organic Chemistry and Biochemistry Academy of Sciences of the Czech Republic
    Inventors: Antonin Holy, Marcela Krecmerova, Alois Piskala, Graciela Andrei, Erik De Clercq, Robert Snoeck, Johan Neyts, Lieve Naesens