Patents by Inventor Graeme Cameron
Graeme Cameron has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230015617Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: ApplicationFiled: September 9, 2021Publication date: January 19, 2023Inventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent M. Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Publication number: 20220387544Abstract: The invention relates to Pol? inhibitors for use in the treatment of a cancer associated with a Shieldin deficiency and to pharmaceutical compositions comprising said Pol? inhibitors.Type: ApplicationFiled: August 9, 2019Publication date: December 8, 2022Applicant: Artios Pharma LimitedInventors: Helen Marie Ruth ROBINSON, Graeme Cameron Murray SMITH, Christopher James LORD, Diana ZATREANU
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Patent number: 11160803Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: GrantFiled: September 11, 2019Date of Patent: November 2, 2021Assignee: KUDOS PHARMACEUTICALS LIMITEDInventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent Junior M Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Publication number: 20210244706Abstract: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.Type: ApplicationFiled: September 28, 2020Publication date: August 12, 2021Inventors: Alan Ashworth, Stephen Jackson, Niall Martin, Graeme Cameron Murray Smith
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Publication number: 20200000802Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: ApplicationFiled: September 11, 2019Publication date: January 2, 2020Inventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent Junior M Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Patent number: 10449192Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: GrantFiled: February 26, 2018Date of Patent: October 22, 2019Assignee: KUDO PHARMACEUTICALS LIMITEDInventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent Junior M Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Patent number: 10452077Abstract: Autonomous personal mobility systems including one or more personal mobility vehicles, each personal mobility vehicle including a navigation system configured to provide autonomous point-to-point navigation within a specified geographic area, and one or more sensors configured to detect obstructions proximate to the personal mobility vehicle, so as to enable the navigation system to avoid the detected obstructions. The system includes one or more kiosks configured to store the one or more personal mobility vehicles and charge the one or more personal mobility vehicles while stored. In some examples, the systems include a smartphone app interface to the navigation system.Type: GrantFiled: September 18, 2017Date of Patent: October 22, 2019Assignee: Ford Global Technologies LLCInventors: Andrew Louey, Gaetano D'Agata, Graeme Cameron, Howard Schulz, David Evans
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Patent number: 10343503Abstract: Linear motor actuated moonroofs are provided to include first and second channels and a glass sheet with a first and second edge each contained in the first and second channel, respectively. Each of the first and second channel has a plurality of magnets, which are configured to interact with a plurality of coils positioned on the top and/or bottom surface of the glass sheet proximate to the first and second edges. The plurality of coils are selectively energized by a control module to induce a movement of the glass sheet relative to the first and second channels. In some examples, the moonroof and associated components are contained within a cassette. The plurality of coils are preferably affixed to the glass sheet surfaces by a lithographic or silk-screen printing process.Type: GrantFiled: May 17, 2018Date of Patent: July 9, 2019Assignee: Ford Global Technologies LLCInventors: Andrew Louey, Graeme Cameron
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Patent number: 10286879Abstract: A window washer fluid reservoir is provided for a motor vehicle. The reservoir includes a flattened washer fluid tank having an outer wall contoured to hug a firewall of the vehicle.Type: GrantFiled: September 9, 2014Date of Patent: May 14, 2019Assignee: Ford Global Technologies, LLCInventors: Graeme Cameron, Salman Nazir Shami
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Publication number: 20190054808Abstract: Linear motor actuated moonroofs are provided to include first and second channels and a glass sheet with a first and second edge each contained in the first and second channel, respectively. Each of the first and second channel has a plurality of magnets, which are configured to interact with a plurality of coils positioned on the top and/or bottom surface of the glass sheet proximate to the first and second edges. The plurality of coils are selectively energized by a control module to induce a movement of the glass sheet relative to the first and second channels. In some examples, the moonroof and associated components are contained within a cassette. The plurality of coils are preferably affixed to the glass sheet surfaces by a lithographic or silk-screen printing process.Type: ApplicationFiled: May 17, 2018Publication date: February 21, 2019Inventors: Andrew Louey, Graeme Cameron
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Patent number: 10034884Abstract: There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.Type: GrantFiled: June 19, 2017Date of Patent: July 31, 2018Assignee: KuDOS Pharmaceuticals LimitedInventors: Heather Mary Ellen Duggan, Frederic Georges Marie Leroux, Karine Fabienne Malagu, Niall Morrison Barr Martin, Keith Menear, Graeme Cameron Murray Smith
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Publication number: 20180185363Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: ApplicationFiled: February 26, 2018Publication date: July 5, 2018Inventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent Junior M Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Publication number: 20180101179Abstract: Autonomous personal mobility systems including one or more personal mobility vehicles, each personal mobility vehicle including a navigation system configured to provide autonomous point-to-point navigation within a specified geographic area, and one or more sensors configured to detect obstructions proximate to the personal mobility vehicle, so as to enable the navigation system to avoid the detected obstructions. The system includes one or more kiosks configured to store the one or more personal mobility vehicles and charge the one or more personal mobility vehicles while stored. In some examples, the systems include a smartphone app interface to the navigation system.Type: ApplicationFiled: September 18, 2017Publication date: April 12, 2018Inventors: Andrew Louey, Gaetano D'Agata, Graeme Cameron, Howard Schulz, David Evans
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Publication number: 20170319543Abstract: The present invention relates to the recognition that inhibition of the base excision repair pathway is selectively lethal in cells which are deficient in HR dependent DNA DSB repair. Methods and means relating to the treatment of cancers which are deficient in HR dependent DNA DSB repair using inhibitors which target base excision repair components, such as PARP, is provided herein.Type: ApplicationFiled: May 12, 2017Publication date: November 9, 2017Inventors: Alan Ashworth, Stephen Jackson, Niall Martin, Graeme Cameron Murray Smith
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Publication number: 20170281637Abstract: There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.Type: ApplicationFiled: June 19, 2017Publication date: October 5, 2017Inventors: Heather Mary Ellen Duggan, Frederic Georges Marie Leroux, Karine Fabienne Malagu, Niall Morrison Barr Martin, Keith Menear, Graeme Cameron Murray Smith
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Publication number: 20170226124Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X=NRX then n is 1 or 2 and if X=CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20 heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1 and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: ApplicationFiled: January 20, 2017Publication date: August 10, 2017Inventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent Junior M. Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Patent number: 9717736Abstract: There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.Type: GrantFiled: June 8, 2015Date of Patent: August 1, 2017Assignee: Kudos Pharmaceuticals LimitedInventors: Heather Mary Ellen Duggan, Frederic Georges Marie Leroux, Karine Fabienne Malagu, Niall Morrison Barr Martin, Keith Menear, Graeme Cameron Murray Smith
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Patent number: 9566276Abstract: Compounds of the formula (I): wherein A and B together represent an optionally substituted, fused aromatic ring; X can be NRX or CRXRY; if X?NRX then n is 1 or 2 and if X?CRXRY then n is 1; RX is selected from the group consisting of H, optionally substituted C1-20 alkyl, C5-20 aryl, C3-20heterocyclyl, amido, thioamido, ester, acyl, and sulfonyl groups; RY is selected from H, hydroxy, amino; or RX and RY may together form a spiro-C3-7 cycloalkyl or heterocyclyl group; RC1and RC2 are both hydrogen, or when X is CRXRY, RC1, RC2, RX and RY, together with the carbon atoms to which they are attached, may form an optionally substituted fused aromatic ring; and R1 is selected from H and halo.Type: GrantFiled: September 14, 2015Date of Patent: February 14, 2017Assignee: KUDOS PHARMACEUTICALS LIMITEDInventors: Niall Morrison Barr Martin, Graeme Cameron Smith, Stephen Philip Jackson, Vincent Junior M Loh, Xiao-Ling Fan Cockcroft, Ian Timothy Williams Matthews, Keith Allan Menear, Frank Kerrigan, Alan Ashworth
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Publication number: 20160067258Abstract: There is provided a compound of formula I: or a pharmaceutically acceptable salt thereof. There are also provided processes for the manufacture of a compound of Formula 1, and the use of a compound of Formula 1 as a medicament and in the treatment of cancer.Type: ApplicationFiled: June 8, 2015Publication date: March 10, 2016Inventors: Heather Mary Ellen Duggan, Frederic Georges Marie Leroux, Karine Fabienne Malagu, Niall Morrison Barr Martin, Keith Menear, Graeme Cameron Murray Smith
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Publication number: 20160068140Abstract: A window washer fluid reservoir is provided for a motor vehicle. The reservoir includes a flattened washer fluid tank having an outer wall contoured to hug a firewall of the vehicle.Type: ApplicationFiled: September 9, 2014Publication date: March 10, 2016Inventors: Graeme Cameron, Salman Nazir Shami