Patents by Inventor Graeme F. Bryce

Graeme F. Bryce has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tetrahydronaphthalene and indane compounds useful for reversing the photo-damage in sun-exposed skin
    Patent number: 5075333
    Abstract: The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinkling, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein n represents 1 or 2, Z represents--SR, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower alkyl, mono-lower-alkylamino, di-lower-alkylamino, mono-lower-alkylamido, or di-lower-alkylamidoand pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: December 24, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Graeme F. Bryce, Stanley S. Shapiro
  • Tetrahydronaphthalene and indane compounds useful for reversing the photodamage in sun-exposed skin
    Patent number: 5061733
    Abstract: The use of compounds of formula I as topical agents to combat the disorders of the skin produced by photodamage which disorders include: wrinklin, elastosis and premature aging is described. Compounds of formula I are ##STR1## wherein n represents 1 or 2, Z represents --S(O)R, wherein R represents lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkoxy-lower-alkyl, lower-alkanoyl-lower-alkyl, hydroxy-lower-alkyl, halo-lower-alkyl, lower-carbalkoxy-lower-alkyl, lower-alkoxy, hydroxy, mono-lower-alkyl amino or di-lower-alkylaminoand pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: May 8, 1990
    Date of Patent: October 29, 1991
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Graeme F. Bryce, Stanley S. Shapiro