Patents by Inventor Graeme James Dykes

Graeme James Dykes has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and pharmaceutical compositions thereof for the treatment of proliferative disorders
    Patent number: 9062051
    Abstract: The present invention discloses compounds according to Formula I: wherein R1, R2, R3, R4, L, and X are as defined herein. The present invention relates to compounds, methods for their production, pharmaceutical compositions comprising the same, and their use in the prophylaxis and/or treatment of inflammatory conditions, type 2 diabetes, neurological and/or neurodegenerative diseases, autoimmune diseases, proliferative diseases (in particular metastatic diseases, and/or cancer), abnormal angiogenesis associated diseases, degradation of cartilage, and/or disruption of cartilage homeostasis, in particular in the prophylaxis and/or treatment of cancer. The present invention also discloses methods of treatment using the same compounds, for the prophylaxis and/or treatment of said diseases by administering the compound of the invention.
    Type: Grant
    Filed: August 18, 2014
    Date of Patent: June 23, 2015
    Assignee: GALAPAGOS NV
    Inventors: Laurent Raymond Maurice Sanière, Jacques Huck, Graeme James Dykes, Benoit Antoine Schmitt, Javier Blanc, Anna Sara Butler, Florence Marie-Emilie Bonnaterre, Stéphane Nicolas Alain Beaumont
  • Novel compounds useful for the treatment of degenerative & inflammatory diseases
    Publication number: 20080242661
    Abstract: The present invention relates to compounds that are inhibitors of PDE1A, a phosphodiesterase that is involved in the modulation of the degradation of cartilage, joint degeneration and diseases involving such degradation and/or inflammation.
    Type: Application
    Filed: December 10, 2007
    Publication date: October 2, 2008
    Inventors: Graeme James Dykes, Stephen Robert Fletcher, Christel Jeanne Marie Menet, Nuria Merayo Merayo, Benoit Antoine Schmitt