Abstract: The present disclosure relates to a formulation for a wide variety of poorly soluble drugs to improve bioavailability using a solid self-emulsifying drug delivery system. Compositions of the present disclosure can be used for improved delivery of hydrophobic or lipophilic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals, and diagnostic agents.

Abstract: The invention relates to a leak detector (10) for detecting leaked liquid. The leak detector (10) comprises a flexible and elongate fastener (12) configured to fit around a liquid containing pipe to thereby attach the leak detector to the liquid containing pipe. The leak detector also comprises a leak sensor and a housing (14) containing electrical circuitry. The leak sensor (is) comprised in at least one of the fastener and the housing. The leak sensor is configured to sense liquid leaking from the liquid containing pipe with the electrical circuitry being operative to detect a leak in dependence on an output from the leak sensor. The leak detector is configured such that the housing (14) and the fastener (12) are abreast.

Abstract: The present disclosure relates to a formulation for a wide variety of poorly soluble drugs to improve bioavailability using a solid self-emulsifying drug delivery system. Compositions of the present disclosure can be used for improved delivery of hydrophobic or lipophilic pharmaceutical active ingredients, such as drugs, nutritional agents, cosmeceuticals, and diagnostic agents.

Abstract: The invention relates to a leak detector (10) for detecting leaked liquid. The leak detector (10) comprises a flexible and elongate fastener (12) configured to fit around a liquid containing pipe to thereby attach the leak detector to the liquid containing pipe. The leak detector also comprises a leak sensor and a housing (14) containing electrical circuitry. The leak sensor (is) comprised in at least one of the fastener and the housing. The leak sensor is configured to sense liquid leaking from the liquid containing pipe with the electrical circuitry being operative to detect a leak in dependence on an output from the leak sensor. The leak detector is configured such that the housing (14) and the fastener (12) are abreast.

Abstract: A solid form comprising at least one film enrobing a compacted fill material comprising a pressure sensitive multiparticulate and at least one cushioning agent, in which the multiparticulate and/or the cushioning agent comprises at least one active material, having low friability and wherein the compacted fill material has a density of at least 0.5 g/ml based on the total solid volume of the solid form and a tensile strength of less than 0.9 MPa.

Abstract: A solid form comprising at least one film enrobing a compacted fill material wherein: i) the compacted fill material comprises at least one active material; ii) the solid form shows a weight loss that is less than 1% during a 30 minutes USP friability test United States Pharmacopeia (USP) 29 Test Number 1216 (page 3046); iii) the compacted fill material has a density of at least 0.5 g/ml based on the total solid volume of the solid form and a tensile strength of less than 0.9 MPa; and iv) the compacted fill material is present in the solid form in at least a first zone and a second zone and the active material is present in at least one of the zones.

Abstract: A solid form comprising at least one film enrobing a compacted fill material having at least one active material contained in a matrix and having low friability, a density of at least 0.5 g/ml based on the total solid volume of the solid form and a tensile strength less than 0.9 MPa and which exhibits a controlled release profile for release of the active material. Zero order release may be achieved.

Abstract: An enrobed solid form comprising a film enrobing a compacted fill material having at least one active material, the solid form shows a weight loss that is less than 1% during a 30 minutes USP Friability Test, the fill material having a density of at least 0.5 g/ml based on the total solid volume of the solid form and a tensile strength less than 0.9 MPa, and the at least one active material within the solid form has an immediate release profile. The solid form is useful in effective delivery of high dose levels of active material.