Patents by Inventor Graeme McRobbie

Graeme McRobbie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CASSETTE FOR STABILISED RADIOLABELLING REACTION
    Publication number: 20230120841
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).
    Type: Application
    Filed: December 21, 2022
    Publication date: April 20, 2023
    Inventors: Torgrim Engell, Alexander JACKSON, Imtiaz Ahmed KAHN, Alan Peter CLARKE, Graeme MCROBBIE, Julian Grigg
  • Stabilized radiolabelling reaction
    Patent number: 11565257
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).
    Type: Grant
    Filed: March 29, 2019
    Date of Patent: January 31, 2023
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Alexander Jackson, Imtiaz Ahmed Khan, Alan Peter Clarke, Graeme McRobbie, Julian Grigg
  • USE OF CYCLODEXTRINS AS A RADIOSTABILIZER
    Publication number: 20220409752
    Abstract: The present invention provides a radiopharmaceutical composition comprising the following four components: (i) a radio-labelled compound; (ii) ethanol; (iii) a stabilizer of the radio-labelled compound; and (iv) a cyclodextrin. The present invention also provides a radiopharmaceutical composition comprising: (i) a radio-labelled compound; (ii) a stabilizer of the radio-labelled compound, wherein the stabilizer comprises: ascorbic acid, aspartic acid, cysteine, maleic acid, gentisic acid, glutathione, glutamic acid, mannitol, nicotinamide, calcium chloride, N-t-butyl-alpha-phenylnitrone (PBN), tartaric acid, para-aminobenzoic acid (pABA), chloride ions or salts or combinations thereof; and (iii) a cyclodextrin.
    Type: Application
    Filed: October 21, 2020
    Publication date: December 29, 2022
    Inventors: Kristine WIKENE, Imtiaz Ahmed KAHN, Graeme McRobbie
  • RADIOTRACER COMPOSITIONS AND METHODS
    Publication number: 20220202965
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Application
    Filed: March 15, 2022
    Publication date: June 30, 2022
    Inventors: Torgrim ENGELL, Gareth Simon GETVOLDSEN, Andreas Richard MEIJER, Imtiaz Ahmed KHAN, Graeme MCROBBIE, Robert James NAIRNE
  • Radiotracer compositions and methods
    Patent number: 11311636
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: April 26, 2022
    Assignee: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Graeme McRobbie, Robert James Nairne
  • PURIFICATION METHOD AND COMPOSITIONS
    Publication number: 20210330824
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of purifying a radiotracer which comprises 18F-labelled aminoxy-functionalised biological targeting moiety. The invention provides radioprotectant-containing radiopharmaceutical compositions of the tracers, as well as associated automated methods and cassettes.
    Type: Application
    Filed: May 7, 2021
    Publication date: October 28, 2021
    Inventors: Torgrim Engell, Andreas Meijer, Imtias Ahmed Khan, Robert James Nairne, Graeme McRobbie
  • SOLID PHASE EXTRACTION
    Publication number: 20210023558
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is amenable to automation. In particular, the method of the present invention comprises a method of purification carried out by means of solid phase extraction (SPE) alone.
    Type: Application
    Filed: March 29, 2019
    Publication date: January 28, 2021
    Inventors: Torgrim Engell, Alexander JACKSON, Alexander Imtiaz KAHN, Alan P. CLARKE, Walter Graeme MCROBBIE, Julian Grigg
  • STABILISED RADIOLABELLING REACTION
    Publication number: 20210017098
    Abstract: The present invention provides a method for the synthesis of an injectable composition comprising a [18F]-labelled pyridaben derivative that is advantageous over prior methods. In particular, the method of the present invention comprises a method of radiosynthesis that permits a more facile purification using solid phase extraction (SPE).
    Type: Application
    Filed: March 29, 2019
    Publication date: January 21, 2021
    Inventors: Torgrim Engell, Alexander JACKSON, Alexander Imtiaz KAHN, Alan P. CLARKE, Walter Graeme MCROBBIE, Julian Grigg
  • Alkylation method
    Patent number: 10759747
    Abstract: The present invention relates to a method of radiochemical synthesis. Novel methods useful in the synthesis of a positron emission tomography (PET) tracer, and novel intermediates useful in said method are provided that have advantages over known methods.
    Type: Grant
    Filed: May 2, 2017
    Date of Patent: September 1, 2020
    Assignees: GE HEALTHCARE LIMITED, KINGS COLLEGE LONDON
    Inventors: Imtiaz Khan, Graeme McRobbie, Anna Kirjavainen
  • RADIOTRACER COMPOSITIONS AND METHODS
    Publication number: 20190275182
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Application
    Filed: April 4, 2019
    Publication date: September 12, 2019
    Inventors: Torgrim ENGELL, Gareth Simon GETVOLDSEN, Andreas Richard MEIJER, Imtiaz Ahmed KHAN, Graeme MCROBBIE, Robert James NAIRNE
  • ALKYLATION METHOD
    Publication number: 20190161440
    Abstract: The present invention relates to a method of radiochemical synthesis. Novel methods useful in the synthesis of a positron emission tomography (PET) tracer, and novel intermediates useful in said method are provided that have advantages over known methods.
    Type: Application
    Filed: May 2, 2017
    Publication date: May 30, 2019
    Inventors: Imtiaz KHAN, Graeme MCROBBIE, Anna KIRJAVAINEN
  • Radiotracer compositions and methods
    Patent number: 10300156
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: May 28, 2019
    Assignee: GE Healthcare Limited
    Inventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, Imtiaz Ahmed Khan, Robert James Nairne, Graeme McRobbie
  • RADIOTRACER COMPOSITIONS AND METHODS
    Publication number: 20160303263
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to radiotracer compositions which comprises 18F-labelled c-Met binding peptides. The invention provides said compositions, as well as associated automated methods of preparation and cassettes.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 20, 2016
    Inventors: Torgrim Engell, Gareth Simon Getvoldsen, Andreas Richard Meijer, IMTIAZ Ahmed KHAN, Robert James Nairne, Graeme McRobbie
  • PURIFICATION METHOD AND COMPOSITIONS
    Publication number: 20160303262
    Abstract: The present invention relates to the field of radiopharmaceuticals for in vivo imaging, in particular to a method of purifying a radiotracer which comprises 18F-labelled aminoxy-functionalised biological targeting moiety. The invention provides radioprotectant-containing radiopharmaceutical compositions of the tracers, as well as associated automated methods and cassettes.
    Type: Application
    Filed: December 18, 2014
    Publication date: October 20, 2016
    Applicant: GE HEALTHCARE LIMITED
    Inventors: Torgrim Engell, Andreas Richard Meijer, IMTIAZ Ahmed KHAN, Robert James Nairne, Graeme McRobbie