Patents by Inventor Graham Albert Edwin GARNETT

Graham Albert Edwin GARNETT has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMIDAZOTHIENOPYRIDINE COMPOUNDS AND METHODS OF USE
    Publication number: 20240124484
    Abstract: Disclosed herein are compounds having Formula I, or a pharmaceutically acceptable salt thereof, wherein R, R1, R2, R3, and Spacer are described herein. Also disclosed are methods of making and using such compounds, as well as pharmaceutical compositions comprising the compounds, for the treatment of a disease such as cancer.
    Type: Application
    Filed: December 14, 2021
    Publication date: April 18, 2024
    Inventors: Graham Albert Edwin GARNETT, Michael G. Brant
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20230317700
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: January 20, 2023
    Publication date: October 5, 2023
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 11591405
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: July 26, 2019
    Date of Patent: February 28, 2023
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, Stuart Daniel Barnscher
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20190345254
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: July 26, 2019
    Publication date: November 14, 2019
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 10450378
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: October 22, 2019
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josee Bourque, Stuart Daniel Barnscher
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 10414822
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: January 16, 2018
    Date of Patent: September 17, 2019
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, Stuart Daniel Barnscher
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20180208667
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: January 16, 2018
    Publication date: July 26, 2018
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER
  • Cytotoxic and anti-mitotic compounds, and methods of using the same
    Patent number: 9879086
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Grant
    Filed: September 17, 2015
    Date of Patent: January 30, 2018
    Assignee: ZYMEWORKS INC.
    Inventors: Geoffrey C. Winters, James R. Rich, Graham Albert Edwin Garnett, Alexander Laurence Mandel, Tom Han Hsiao Hsieh, Elyse Marie Josée Bourque, Stuart Daniel Barnscher
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20170247408
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: September 17, 2015
    Publication date: August 31, 2017
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josee BOURQUE, Stuart Daniel BARNSCHER
  • CYTOTOXIC AND ANTI-MITOTIC COMPOUNDS, AND METHODS OF USING THE SAME
    Publication number: 20160075735
    Abstract: Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
    Type: Application
    Filed: September 17, 2015
    Publication date: March 17, 2016
    Inventors: Geoffrey C. WINTERS, James R. RICH, Graham Albert Edwin GARNETT, Alexander Laurence MANDEL, Tom Han Hsiao HSIEH, Elyse Marie Josée BOURQUE, Stuart Daniel BARNSCHER