Abstract: A drug delivery device may be configured to delivery an active pharmaceutical ingredient (API) to a subject via the subject's oral-gastrointestinal (GI) tract. The drug delivery device may be configured to deliver a payload of an API while within the GI tract of the subject. The drug delivery device may include a reservoir, a potential energy source, a plurality of outlets, and a plurality of valves, wherein each outlet has a corresponding valve. The drug delivery device may further include a sensor configured to sense the direction of gravity, and the valves may be selectively opened based on a sensed direction of gravity. Thus, the drug delivery device may dispense a dose of API within the GI tracts of the subject based at least in part on the sensed direction of gravity.

Abstract: A drug delivery device for administration to a subject may include a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device may also include a trigger operatively associated with the potential energy source. The trigger may be configured to actuate at a predetermined location within the subject to deploy a jet of the active pharmaceutical ingredient into a tissue of an adjacent portion of the gastrointestinal tract. In some instances, the jet may be deployed into tissue of the stomach and/or small intestine of the subject. Further, in some embodiments, the operating parameters of the jet may be selected such that the jet penetrates the tissue of the gastrointestinal tract to form a depot of the active pharmaceutical ingredient disposed within the tissue.

Abstract: A device may be configured with a housing having a reservoir and an outlet separated by a heat rupturable membrane. The membrane may serve to separate a material held within the reservoir from the outlet until the membrane is ruptured. The membrane may include a heater configured to selectively rupture the membrane when actuated. The heater may be physically removed and/or thermally insulated from at least one of an environment surrounding the device and the reservoir.

Abstract: A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.

Abstract: A reservoir provided in a hard-point fixture is pre-loaded with a curable adhesive, where the reservoir is protected from the curing radiation. The fixture is placed on a target surface and the adhesive is extruded from the reservoir into a space between the fixture and the target surface. An irradiating device to cure the adhesive is provided in the fixture and activated to couple the fixture to the surface. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.

Abstract: A hard-point fixture placement system places a fixture that is pre-loaded with a curable adhesive by mechanically extruding the adhesive between the fixture and a target surface to which the fixture is to be attached. The placement system includes an irradiating device to cure the adhesive. The hard-point fixture stores the adhesive in a reservoir that is protected from the curing radiation. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.

Abstract: A hard-point fixture placement system places a fixture that is pre-loaded with a curable adhesive by mechanically extruding the adhesive between the fixture and a target surface to which the fixture is to be attached. The placement system includes an irradiating device to cure the adhesive. The hard-point fixture stores the adhesive in a reservoir that is protected from the curing radiation. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.

Abstract: A reservoir provided in a hard-point fixture is pre-loaded with a curable adhesive, where the reservoir is protected from the curing radiation. The fixture is placed on a target surface and the adhesive is extruded from the reservoir into a space between the fixture and the target surface. An irradiating device to cure the adhesive is provided in the fixture and activated to couple the fixture to the surface. Once the curing process is complete, the fixture is released from the placement system leaving the fixture affixed to the target surface.

Abstract: A hybrid adhesion system includes an adhesion head including at least one suction cup and a handle and a vacuum generator mechanically coupled to the adhesion head. The vacuum generator includes at least one pneumatic cylinder having an internal volume in fluid communication with the at least one suction cup and a piston having a piston rod mechanically coupled to a manual actuator.

Abstract: A hybrid adhesion system includes an adhesion head including at least one suction cup and a handle and a vacuum generator mechanically coupled to the adhesion head. The vacuum generator includes at least one pneumatic cylinder having an internal volume in fluid communication with the at least one suction cup and a piston having a piston rod mechanically coupled to a manual actuator.