Patents by Inventor Graham Buckton

Graham Buckton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Free base crystals
    Patent number: 9630971
    Abstract: The present invention relates to crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, and methods of making and using such crystals.
    Type: Grant
    Filed: June 20, 2014
    Date of Patent: April 25, 2017
    Assignee: INTRA-CELLULAR THERAPIES, INC.
    Inventors: Takashi Abe, Graham Buckton, Robert Davis, Mark Hooper, Peng Li, Hideaki Maruyama, Masahiro Takasuga, Lawrence P. Wennogle, Yuhei Yamamoto, Hironori Yamashita
  • Salt crystals
    Patent number: 9469647
    Abstract: The present invention relates to acid addition salt and salt crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, composition comprising the same and the method of making and using such salt and crystal.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: October 18, 2016
    Assignee: INTRA-CELLULAR THERAPIES, INC.
    Inventors: Peng Li, Lawrence P. Wennogle, Robert Davis, Graham Buckton, Mark Hooper
  • FREE BASE CRYSTALS
    Publication number: 20160145261
    Abstract: The present invention relates to crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, and methods of making and using such crystals.
    Type: Application
    Filed: June 20, 2014
    Publication date: May 26, 2016
    Applicant: INTRA-CELLULAR THERAPIES, INC.
    Inventors: Takashi ABE, Graham Buckton, Robert DAVIS, Mark HOOPER, Peng LI, Hideaki MARUYAMA, Masahiro TAKASUGA, Lawrence P. Wennogle, Yuhei YAMAMOTO, Hinori YAMASHITA
  • SALT CRYSTALS
    Publication number: 20150259353
    Abstract: The present invention relates to acid addition salt and salt crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, composition comprising the same and the method of making and using such salt and crystal
    Type: Application
    Filed: June 21, 2013
    Publication date: September 17, 2015
    Inventors: Peng Li, Lawrence P. Wennogle, Robert Davis, Graham Buckton, Mark Hooper
  • Solid Dispersion of Hydrophobic Bioactive
    Publication number: 20080227855
    Abstract: A stable composition of an amorphous component (such as a bioactive) and a carrier polymer is formed by mixing a bridging polymer with the bioactive and the carrier polymer, wherein the bridging polymer is a hydrogen bond donor to both the bioactive and the carrier polymer, thereby forming a composition in which the bioactive and the carrier polymer have less of a tendency to crystallise than if the bridging polymer were not present.
    Type: Application
    Filed: February 10, 2006
    Publication date: September 18, 2008
    Inventors: Graham Buckton, Stephen Brocchini, John Fletcher, Hisham Al-Obaidi
  • Pharmaceutical aerosol formulation
    Patent number: 7163672
    Abstract: The invention relates to a pharmaceutical aerosol formulation comprising a surfactant that is an alkyl-polyglycoside of formula I, wherein DP is the average degree of polymerisation and has a value of from 1 to 4, and R is an alkyl chain or a mixture of alkyl chains having a chain length of from 6 to 22 carbon atoms; or a derivative thereof for the administration of a medicament for inhalation.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: January 16, 2007
    Assignee: AstraZeneca AB
    Inventors: Graham Buckton, Angela Columbano, Martin Grosvenor, Philip Wikeley
  • Pharmaceutical aerosol formulation
    Publication number: 20040082520
    Abstract: The invention relates to a pharmaceutical aerosol formulation comprising a surfactant that is an alkyl-polyglycoside of formula I, wherein DP is the average degree of polymerisation and has a value of from 1 to 4, and R is an alkyl chain or a mixture of alkyl chains having a chain length of from 6 to 22 carbon atoms; or a derivative thereof for the administration of a medicament for inhalation.
    Type: Application
    Filed: November 25, 2003
    Publication date: April 29, 2004
    Inventors: Graham Buckton, Angela Columbano, Martin Grosvenor, Philip Wikeley
  • Particulate inhalation carrier
    Publication number: 20040062719
    Abstract: The present invention provides a particulate substrate suitable for carrying a drug for delivery, comprising a substantially crystalline core and a surface coating, wherein the particulate substrate has a proportion of amorphous character of 2% of greater by weight of particulate substrate, and a process for the production of carrier particles comprising the steps of: a) mixing crystalline particles having an average diameter greater than 10 &mgr;m with at least partially amorphous particles having average diameters less than 10 &mgr;m; b) exposing the mixture to conditions capable of inducing crystallization of the amorphous particles for a predetermined period in order that partial crystallization takes place.
    Type: Application
    Filed: October 20, 2003
    Publication date: April 1, 2004
    Inventors: Graham Buckton, Dima Al-Hadithi, Stephen Brocchini