Abstract: Systems for identifying one or more defined objects and alerting a user, and components of such systems. The system includes: a plurality of sensors configured to sense environmental information within a defined range; a plurality of alert devices configured to emit an alert; and a communications module communicatively connected to the sensors, the devices, and one or more processors configured to assess sensed environmental information to identify the one or more defined objects. The communications module is configured so that responsive to communicating with the sensors, the one or more processors, and the alert devices, the module communicates an alert signal to each alert device registered with a sensing zone to cause each registered alert device to emit the alert.

Abstract: A disclosed method may include receiving user information for electronically filing or updating an electronic data sheet that corresponds to a user and a domain; maintaining a record of past electronic activities by the user; electronically receiving interchange data associated with interchanges executed by the user; automatically generating the electronic data sheet for the user based on the user information and the interchange data, the electronic data sheet indicating a finalized amount of resources to be transmitted to the domain; and electronically adjusting an electronic value for the user according to a remittance risk determination that is based on the interchange data and the record of past electronic activities by the user, the adjusted electronic value indicating a maximum amount of resources for which an online software platform will transmit and receive protocols to enable providing by the online software platform the maximum amount of resources.

Abstract: Systems and methods are disclosed for automated preparation and transmission of electronic registrations, data sheets and resources. This may include electronically initiating a process to collect data via a graphical user interface (GUI) to facilitate automated preparation of an electronic registration, including electronically obtaining a pre-existing entity identifier. The system may use the entity identifier to perform automated actions to electronically collect one or more support content. The system may generate the electronic registration based on the one or more support content and also receives interchange data. The system then automatically generates an electronic data sheet based on the registration and interchange data. The system may then electronically file the generated electronic data sheet, electronically issuing an alert to electronically request additional resources and automatically transmitting the finalized amount of resources to the domain.

Abstract: A system for automated preparation and submission of electronic registration may obtain a pre-existing entity identifier that had been previously used by an electronic system of at least one authority entity to identify a primary entity. The system may electronically associate the pre-existing entity identifier with the primary entity and use it to perform automated actions to electronically collect one or more support content from the Internet or other sources regarding the primary entity. The system may electronically identify data from the support content relevant to the electronic registration and electronically extract the identified data from the support content. The system may also electronically verify the extracted data before electronically generating and submitting the electronic registration based on the extracted data. An adaptive UI may be automatically modified in response to a determination whether to electronically present a query via the adaptive UI for the supplemental data.

Abstract: The invention relates to a plate (10) for temporarily bridging fragments of a fracture having a proximal portion (11), a distal portion (12), and an intermediate portion (13) disposed between the proximal portion (11) and the distal portion (12). The proximal portion (11) has a proximal attachment zone (14) adapted to be applied and attached to a first tubular bone (1). The distal portion (12) has a distal attachment zone (15) adapted to be applied and attached to a second tubular bone (2). The intermediate portion (13) is adapted to bridge a joint (3) between the first tubular bone (1) and the second tubular bone (2) and thereby at least one further bone, in particular without attachment to the at least one further bone. The plate (10) has at least one curved region (16, 17) between the proximal attachment zone (14) and the distal attachment zone (15). Furthermore, the invention relates to a method for treating a complex joint fracture, in which in particular such a plate can be used.

Abstract: System/method identifying a defined object (e.g., hazard): a sensor detecting and defining a digital representation of an object; a processor (connected to the sensor) which executes two techniques to identify a signature of the defined object; a memory (connected to the processor) storing reference data relating to two signatures derived, respectively, by the two techniques; responsive to the processor receiving the digital representation from the sensor, the processor executes the two techniques, each technique assessing the digital representation to identify any signature candidate defined by the object, derive feature data from each identified signature candidate, compare the feature data to the reference data, and derive a likelihood value of the signature candidate corresponding with the respective signature; combining likelihood values to derive a composite likelihood value and thus determine whether the object in the digital representation is the defined object.

Abstract: The present invention concerns an air filter cleaning device comprising a rotating stage on which an air filter to be cleaned is seated and rotated about its central axis; and an inner outlet head configured to extend through a central opening of the rotating stage and be vertically moveable between a lower position and an upper position at least parallel to the central axis of the air filter, said outlet head having at least one gas outlet for discharging pressurised air outwardly through at least one wall of the air filter for dislodging contaminants; an outer vacuum head located externally to the air filter for suctioning the contaminants dislodged from the air filter by the inner outlet head wherein the inner outlet head is further configured such that the lower position is located less than abourt 1,500 mm above a support surface for the cleaning device.

Abstract: The present invention concerns an air filter cleaning device having a rotating stage on which an air filter to be cleaned is seated and rotated about its central axis; and an inner outlet head configured to extend through a central opening of the rotating stage and be vertically moveable between a lower position and an upper position at least parallel to the central axis of the air filter, said outlet head having at least one gas outlet for discharging pressurized air outwardly through at least one wall of the air filter for dislodging contaminants; an outer vacuum head located externally to the air filter for suctioning the contaminants dislodged from the air filter by the inner outlet head wherein the inner outlet head is further configured such that the lower position is located less than about 1,500 mm above a support surface for the cleaning device.

Abstract: An apparatus for fabricating an object on a substrate, the apparatus including a plurality of nozzles arranged in an array and each nozzle being in communication with a supply of build material and configured to expel a quantity of the build material therefrom, and also including a controller configured to selectively operate each nozzle to deposit a portion of the build material, responsive to data relating to a geometry of the object. During operation, the controller selectively operates at least some of the nozzles to deposit portions of the build material in specific locations corresponding with the object geometry, wherein at least one of the portions abuts the substrate and the portions are progressively deposited until the portions form the object.

Abstract: Systems for identifying one or more defined objects and alerting a user, and components of such systems. The system includes: a plurality of sensors configured to sense environmental information within a defined range; a plurality of alert devices configured to emit an alert; and a communications module communicatively connected to the sensors, the devices, and one or more processors configured to assess sensed environmental information to identify the one or more defined objects. The communications module is configured so that responsive to communicating with the sensors, the one or more processors, and the alert devices, the module communicates an alert signal to each alert device registered with a sensing zone to cause each registered alert device to emit the alert.

Abstract: A subsea manifold 150 is integrated into a pipeline 22 so as to be deployable to the seabed together with the pipeline, from a pipe-laying vessel. The subsea manifold comprises a hub 106a, 106b for receiving production fluid from at least one subsea christmas tree 54a, 54b, and further comprises a connection 112 for at least one service line 116 connected to a surface supply or control or monitoring facility.

Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.

Abstract: A subsea manifold (150) is integrated into a pipeline (22) so as to be deployable to the seabed together with the pipeline, from a pipe-laying vessel. The subsea manifold comprises a hub (106a, 106b) for receiving production fluid from at least one subsea christmas tree (54a, 54b), and further comprises a connection (112) for at least one service line (116) connected to a surface supply or control or monitoring facility.

Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide is provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.

Abstract: A pharmaceutical composition suitable for oral administration comprising particles of 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2- oxoacetamideis provided. Also provided is a pharmaceutical composition suitable for parenteral administration wherein the composition comprises 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide. The compositions are useful in the treatment of fungal infection in a subject in need thereof.

Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.

Abstract: The invention provides a pyrrole compound, which compound is (a) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)phenyl)-2-oxoacetamide or a deuterated derivative thereof, or (b) 2-(1,5-dimethyl-3-phenyl-1H-pyrrol-2-yl)-N-(4-(4-(5-fluoropyrimidin-2-yl)piperazin-1-yl)-3-hydroxyphenyl)-2-oxoacetamide or a deuterated derivative thereof, or (c) a prodrug of compound (a) or a prodrug of compound (b), or a pharmaceutically acceptable salt or agriculturally acceptable salt of (a), (b) or (c). Also provided are combinations and compositions comprising the compound and known antifungal agents. The invention also relates to the therapeutic use of a compound of the invention in prevention or treatment of fungal diseases.

Abstract: System/method identifying a defined object (e.g., hazard): a sensor detecting and defining a digital representation of an object; a processor (connected to the sensor) which executes two techniques to identify a signature of the defined object; a memory (connected to the processor) storing reference data relating to two signatures derived, respectively, by the two techniques; responsive to the processor receiving the digital representation from the sensor, the processor executes the two techniques, each technique assessing the digital representation to identify any signature candidate defined by the object, derive feature data from each identified signature candidate, compare the feature data to the reference data, and derive a likelihood value of the signature candidate corresponding with the respective signature; combining likelihood values to derive a composite likelihood value and thus determine whether the object in the digital representation is the defined object.

Abstract: The present invention concerns an air filter cleaning device comprising a rotating stage on which an air filter to be cleaned is seated and rotated about its central axis; and an inner outlet head configured to extend through a central opening of the rotating stage and be vertically moveable between a lower position and an upper position at least parallel to the central axis of the air filter, said outlet head having at least one gas outlet for discharging pressurised air outwardly through at least one wall of the air filter for dislodging contaminants; an outer vacuum head located externally to the air filter for suctioning the contaminants dislodged from the air filter by the inner outlet head wherein the inner outlet head is further configured such that the lower position is located less than about 1,500 mm above a support surface for the cleaning device.