Patents by Inventor Graham Erwin

Graham Erwin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION
    Publication number: 20240100191
    Abstract: The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Application
    Filed: July 5, 2023
    Publication date: March 28, 2024
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Aseem Ansari, Graham Erwin, Matthew Grieshop
  • COMPOUNDS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE DISEASES AND DISORDERS
    Publication number: 20230322853
    Abstract: Disclosed herein are compounds (e.g., cancer) comprising a moiety that specifically binds to oligonucleotides comprising one or more repeats of GAAA (e.g., a pyrrole/imidazole polyamide) and bromodomain inhibitor and compositions and methods thereof for use in treating proliferative diseases and disorders.
    Type: Application
    Filed: April 7, 2023
    Publication date: October 12, 2023
    Inventors: Graham Erwin, Michael P. Snyder
  • Methods and compositions for modulating gene expression
    Patent number: 11759533
    Abstract: The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and —B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: September 19, 2023
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Aseem Ansari, Graham Erwin, Matthew Grieshop
  • COMPOUNDS AND METHODS FOR MODULATING FRATAXIN EXPRESSION
    Publication number: 20230241077
    Abstract: The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Application
    Filed: March 17, 2023
    Publication date: August 3, 2023
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Aseem Ansari, Graham Erwin, Matthew P. Grieshop
  • COMPOUNDS AND METHODS FOR MODULATING FRATAXIN EXPRESSION
    Publication number: 20200129522
    Abstract: The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and —B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Application
    Filed: December 11, 2019
    Publication date: April 30, 2020
    Inventors: Aseem Ansari, Graham Erwin, Matthew P. Grieshop
  • Compounds and methods for modulating frataxin expression
    Patent number: 10517877
    Abstract: The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Grant
    Filed: March 29, 2017
    Date of Patent: December 31, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Aseem Ansari, Graham Erwin, Matthew Grieshop
  • METHODS AND COMPOSITIONS FOR MODULATING GENE EXPRESSION
    Publication number: 20180280541
    Abstract: The present technology relates to compositions and methods for modulating expression of genes which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and —B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 4, 2018
    Inventors: Aseem Ansari, Graham Erwin, Matthew Grieshop
  • COMPOUNDS AND METHODS FOR MODULATING FRATAXIN EXPRESSION
    Publication number: 20170281643
    Abstract: The present technology relates to compositions and methods for modulating expression of genes, which include a target oligonucleotide sequence, such as repeats of a particular oligonucleotide sequence containing 3 to 10 nucleotides. In particular aspects, the present technology relates to agents having a formula A-L-B, wherein -L- is a linker; A- is a Brd4 binding moiety; and -B is a nucleic acid binding moiety, such as a polyamide or complementary oligonucleotide, that specifically binds to the target oligonucleotide sequence.
    Type: Application
    Filed: March 29, 2017
    Publication date: October 5, 2017
    Applicant: Wisconsin Alumni Research Foundation
    Inventors: Aseem Ansari, Graham Erwin, Matthew Grieshop