Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Provided herein are methods of treating triple negative breast cancer using an effective amount of Compound (I) represented by the formula: or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor, wherein the checkpoint inhibitor is a PD-1 inhibitor or a PD-L1 inhibitor. Uses of an effective amount of Compound [I] and an effective amount of an immune checkpoint inhibitor, wherein the checkpoint inhibitor is a PD-linhibitor or a PD-L1 inhibitor for treating triple negative breast cancer are also provided herein.

Abstract: The invention is related to a method of treating a subject with acute myeloid leukemia, acute lymphoblastic leukemia, chronic myeloid leukemia, non-Hodgkin’s lymphoma, Burkitt lymphoma, or diffuse large B-cell lymphoma, or myelodysplastic syndrome by administration of Compound (I): (I), or a pharmaceutically acceptable salt thereof.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula (Formula (I)) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: Provided herein are methods of treating cancer using an effective amount of a compound represented by the formula: (I) or a pharmaceutically acceptable salt thereof and an effective amount of an immune checkpoint inhibitor. Also provided are compositions comprising the same compound represented by the formula shown above or a pharmaceutically acceptable salt thereof and an immune checkpoint inhibitor.

Abstract: An onboard electronic device for mounting to a first vehicle. The onboard device may include a capture device configured to capture identifying data associated with a second vehicle. The onboard device may also include a GNSS receiver configured to detect position data based on at least one GNSS signal. The onboard device may further include an onboard controller communicatively coupled to the capture device and the GNSS receiver. The onboard controller may be configured to perform operations including receiving the identifying data from the capture device, receiving the position data from the GNSS receiver, and generating a data report signal based on the identifying data and the position data. The onboard device may further comprise a transmitting antenna configured to transmit the data report signal.

Abstract: Methods and devices for detecting wireless signal absorption using power sensing circuitry. One method includes receiving, by a receiving device having power sensing circuitry, a plurality of wireless signals from a plurality of transmitting devices. The power sensing circuitry may include a local oscillator, a mixer, and a band-pass filter. The method may also include detecting, by the power sensing circuitry, a plurality of power levels for the plurality of wireless signals, where each power level of the plurality of power levels corresponds one of the plurality of wireless signals. The method may further include analyzing, by one or more processors, the plurality of power levels to determine three characteristic power levels of the plurality of power levels. The method may further include calculating, by the one or more processors, an absorption amount based on the three characteristic power levels.

Abstract: Methods and devices for detecting wireless signal absorption using power sensing circuitry. One method includes receiving, by a receiving device having power sensing circuitry, a plurality of wireless signals from a plurality of transmitting devices. The power sensing circuitry may include a local oscillator, a mixer, and a band-pass filter. The method may also include detecting, by the power sensing circuitry, a plurality of power levels for the plurality of wireless signals, where each power level of the plurality of power levels corresponds one of the plurality of wireless signals. The method may further include analyzing, by one or more processors, the plurality of power levels to determine three characteristic power levels of the plurality of power levels. The method may further include calculating, by the one or more processors, an absorption amount based on the three characteristic power levels.

Abstract: A method and apparatus for aligning a vehicle to roadway lane markers includes measuring at least one of a first distance between the vehicle and lane markers for the roadway and a second distance between the vehicle and a recognizable object proximate to the roadway. The location of the vehicle is determined from a satellite navigation system receiver. This location is combined with the first and/or second distances to provide a localization of the vehicle on a high definition (“HD”) map of the roadway. A steering correction signal is generated in response to the comparison of the first distance to the localization of the vehicle on the HD map. The method further includes providing the steering correction signal to an electronic steering controller, wherein the electronic steering controller causes a vehicle steering mechanism to change the position of the vehicle in the roadway lane.

Abstract: An onboard electronic device for mounting to a first vehicle. The onboard device may include a capture device configured to capture identifying data associated with a second vehicle. The onboard device may also include a GNSS receiver configured to detect position data based on at least one GNSS signal. The onboard device may further include an onboard controller communicatively coupled to the capture device and the GNSS receiver. The onboard controller may be configured to perform operations including receiving the identifying data from the capture device, receiving the position data from the GNSS receiver, and generating a data report signal based on the identifying data and the position data. The onboard device may further comprise a transmitting antenna configured to transmit the data report signal.

Abstract: A method of controlling a backing system for a vehicle and trailer assembly comprises initiating a backing system mode with an electronic control unit (ECU) for the backing system when a start system input is received from a control device. At least one input is received by the ECU from the control device which includes information about a desired vehicle action. The ECU interprets from the at least one input the desired vehicle action and calculates a required vehicle response to achieve the desired vehicle action. The ECU then sends a request to at least one vehicle system to perform the calculated vehicle response.

Abstract: An autonomous vehicle includes a vehicle body, a drive mechanism configured to propel the vehicle body, a location module, a communication interface in communication with a traffic control system, and a processing unit in communication with the drive mechanism, the location module, and the communication interface. The processing unit is configured to receive, via the communication interface, a route of a prioritized vehicle and determine, in conjunction with the location module, whether a route of the autonomous vehicle intersects the route of the prioritized vehicle. The processing unit is configured to adjust, using the drive mechanism, one or more of a direction or a speed of the autonomous vehicle based on the determination.

Abstract: An excavation system is disclosed for use with a mobile machine having a work tool. The excavation system may have a speed sensor configured to generate a first signal indicative of a travel speed of the mobile machine, and at least one load sensor configured to generate a second signal indicative of loading of the work tool. The excavation system may also have a controller configured to record values of the first signal during travel of the mobile machine toward a material, and to detect engagement of the work tool with the material based on the second signal. After engagement of the work tool with the material is detected, the controller may be further configured to determine an edge location of the material passed through by the work tool based on values of the first signal recorded prior to engagement detection of the work tool with the material.

Abstract: An autonomous vehicle includes a vehicle body, a drive mechanism configured to propel the vehicle body, a location module, a communication interface in communication with a traffic control system, and a processing unit in communication with the drive mechanism, the location module, and the communication interface. The processing unit is configured to receive, via the communication interface, a route of a prioritized vehicle and determine, in conjunction with the location module, whether a route of the autonomous vehicle intersects the route of the prioritized vehicle. The processing unit is configured to adjust, using the drive mechanism, one or more of a direction or a speed of the autonomous vehicle based on the determination.

Abstract: An excavation system is disclosed as having first and second actuators configured to move a work tool in first and second directions. The second actuator may only be capable of full-range movement when the first actuator is positioned within a sub-range. The excavation system may also have first and second sensors configured to generate first and second signals indicative of first and second actuator movements, and a controller in communication with the first and second sensors. The controller may be configured to command movement of the first actuator to the sub-range, to confirm that the first actuator has moved to the sub-range based on the first signal, to command movement of the second actuator to an end-of-stroke position after the first actuator is confirmed to be within the sub-range, and to selectively record a current position of the second actuator as the end-of-stroke position based on the second signal.

Abstract: An excavation system is disclosed for a machine having a work tool. The excavation system may have at least one sensor to generate a signal indicative of a load exerted on the work tool. The excavation system may also have a lift actuator and a tilt actuator. The excavation system may also have a controller configured to detect engagement of the work tool with a material pile based the signal. The controller may operate the work tool to load the work tool with an amount of material. The controller may determine whether loading of the work tool has been completed. The controller may lift the work tool when the loading has been completed. The controller may also operate the tilt actuator to shake the work tool. Additionally, the controller may cause the machine to withdraw from the material pile after shaking the work tool.

Abstract: An excavation system is disclosed for use with a mobile machine having a work tool. The excavation system may have a first sensor configured to generate a first signal indicative of a distance to an inclined face of the pile of material, and a controller in communication with the first sensor. The controller may be configured to determine a repose angle of the pile of material based on a known edge location of the pile of material and the distance.

Abstract: An excavation system is disclosed for a machine having a work tool. The excavation system may have first and second actuators configured to move the work tool in first and second directions, at least a first valve configured to regulate fluid flow through the first actuator, and at least a second valve configured to regulate fluid flow through the second actuator. The excavation system may also have at least one sensor to generate a first signal indicative of a performance of the first actuator, and a controller in communication with the at least a first valve, the at least a second valve, and the at least one sensor. The controller may be configured to make a first determination that the first actuator is experiencing a stall condition based on the first signal, and to selectively command neutralization of the powertrain and movement of the second actuator based on the first determination.