Abstract: An extrusion apparatus configured to releasably secure therein a filter and two syringes so as to provide stability during the extrusion process. The extrusion apparatus includes a body that is rectangular in form. The body includes a top surface wherein the top surface has formed therein a filter receiving member. The filter receiving member is centrally located on the body. Operably coupled to the filter receiving member on opposing sides thereof is a first syringe channel and a second syringe channel. The first syringe channel and the second syringe channel include a passage having an outer wall. The outer wall of the passage of the first syringe channel and the second syringe channel is annular in form and has a circumferential radius that requires longitudinal insertion of syringes and inhibits the upward movement thereof once the syringes are disposed therein. A heating assembly is further included in the body.

Abstract: An extrusion system that is operable to facilitate the extrusion of a solution through manipulation of a first syringe and a second syringe. The extrusion system includes a tubing network wherein the tubing network includes a first portion coupled to a first port of an extrusion cartridge and a second portion coupled to a second portion of an extrusion cartridge. The first portion of the tubing network includes an inlet line having an inlet valve coupled therewith and a first syringe. A purge line and purge line clamp are further included in the first portion. The second portion includes a second syringe, an exit line and an exit line clamp. The extrusion system utilizes reciprocating movements of the plungers of the first syringe and second syringe to facilitate the passing of the solution through the extrusion cartridge.

Abstract: Disclosed are methods and apparatus for determining the properties of artificial membranes (e.g., artificially prepared lipid bilayers and biomimetic membranes comprising amphiphilic copolymers). Multiple physical properties of the membranes can be determined via a combination of electrical and optical measurements. The optical and electrical measurements can be determined using a single apparatus, which can also be used to prepare the artificial membrane. Methods are also disclosed for determining the effects changes in the composition of the artificial membrane, such as the addition of a drug or a change in lipid content.

Abstract: A single-use, extrusion apparatus and method of using the apparatus. The apparatus includes a first housing member having a first port dimensioned to receive a first needle-tipped syringe, and a first needle path dimensioned to receive a first needle, wherein the first needle path extends from the first port through the first housing member; a second housing member having a second port dimensioned to receive a second needle-tipped syringe, and a second needle path, dimensioned to receive a second needle, wherein the second needle path extends from the second port through the second housing member and is collinear with the first needle path extending through the first housing member; and a membrane filter disposed between the first and second housing members, wherein a total dead-volume of the apparatus, not including the first and second needle paths is less than or equal to about 50 microliters.