Abstract: The invention is in the field of TNF signalling. Compounds have been identified which are capable of modulating signalling of TNF trimers through receptors. Methods of identifying such compounds are therefore provided. The compounds themselves have utility in therapy.

Abstract: The specification describes a method for the production of a hydrochlorination catalyst, comprising the steps of: i) preparing an impregnation solution by combining a source of gold and a ligand in a solvent, wherein the solvent comprises an organic solvent; ii) impregnating a support with the impregnation solution from step (i); and iii) drying the product of step (ii) to obtain the catalyst. Also described are hydrochlorination catalysts comprising a complex of gold and a ligand of Formula (I) supported on a support. These catalysts are particularly suitable for the conversion of acetylene to vinyl chloride monomer.

Abstract: A control system for controlling manipulation of a surgical instrument in response to manipulation of a remote surgeon input device at a remote surgeon's console, the surgical instrument being supported by a surgical robot arm, the surgical instrument comprising an end effector connected to a distal end of a shaft by an articulated coupling, the articulated coupling comprising one or more joints enabling the end effector to adopt a range of attitudes relative to the distal end of the shaft, the control system configured to: receive a command from an input actuated by a user to straighten the surgical instrument; and in response to the received command, to command driving forces to be applied to joint(s) of the articulated coupling to drive the instrument to adopt a predetermined configuration in which the profile of the end effector is most closely aligned with the profile of the distal end of the shaft.

Abstract: The present invention relates to a device for transporting a waste container. The device comprises a mount for mounting the device to a vehicle, a central support for supporting the waste container, the central support being connected to the mount and being extendable to lift the waste container off the ground, an attachment element for attaching the waste container to the central support, and a lifting mechanism for raising and lowering the waste container when the waste container is attached to the central support, wherein the device is configured such that when the device is mounted to the vehicle, a waste container can be lifted and transported by the vehicle in a substantially upright position.

Abstract: Securely redirecting a system service routine via a provider service table. A service call provider is loaded within an operating system executing in a lower trust security zone. The service call provider comprises metadata indicating a system service routine to be redirected to the service call provider. Based on the metadata, a provider service table is built within a higher trust security zone. The service table redirects the system service routine to the service call provider. Memory page(s) associated with the provider service table are hardware protected, and a read-only view is exposed to the operating system. The provider service table is associated with a user-mode process. A service call for a particular system service routine is received by the operation system from the user-mode process and, based on the provider service table being associated with the user-mode process, the service call is directed to the service call provider.

Abstract: A bleach catalyst suitable for use in automatic dishwashing comprising a mixed metal oxide.

Abstract: A needlestick prevention device (100) for an injection needle carried by a needle-bearing member (101) of a syringe (102) is formed as a one-piece moulding and comprises a first part (103) adapted to be attached to the needle-bearing member (101) and a second part (104) providing a shield for the needle and pivotally movable relative to the first part to expose the needle for use. The device is adapted to adopt a first position in which the needle is protected for transport of the device prior to use, a second position in which the needle is exposed for filling of the syringe and injection, a third position in which the needle is protected after filling of the syringe but before injection and a fourth position in which the needle is locked in the device following injection.

Abstract: A control system configured to control manipulation of a surgical instrument in response to manipulation of a remote surgeon input device. The surgical instrument comprises an end effector having opposable first and second end effector elements connected to a shaft by an articulated coupling. The control system receives a command from the surgeon input device to both (i) change the orientation of the end effector, and (ii) open the first and second end effector elements relative to each other. In response to the command to change the orientation of the end effector, the control system determines an angle ? between the longitudinal axis of the articulated coupling and the end effector. In response to the command to open the first and second end effector elements, the control system determines an opening angle ? between the first and second end effector elements.

Abstract: A controller for a pacing device, configured to; receive sensor data comprising respiratory data; determine a respiratory sinus arrhythmia, RSA, factor of a pacing signal based on the sensor data; determine a cardio-respiratory phase synchronisation, CRPS, factor of the pacing signal based on the sensor data; and provide the pacing signal for pacing a heart of a patient in accordance with the RSA factor and the CRPS factor.

Abstract: A control system for a surgical robotic system, the surgical robotic system comprising a remote surgeon console and an articulated surgical robot arm comprising a series of joints extending from a base to a terminal end for attaching to an articulated surgical instrument. The control system comprises a central controller communicatively coupled to and remotely located from an arm controller of the surgical robot arm, the central controller also communicatively coupled to a surgeon input device of the surgeon console.

Abstract: A method of decorating a metal can body and comprising printing a fine pattern onto the can body using a non-varnishable ink, and applying a varnish over the printed fine pattern while the printed non-varnishable ink remains wet. The pattern is configured to give rise to a textured pattern in the varnish once the varnish has dried.

Abstract: Analytics are used for live streaming based on analysis within a shared digital environment. An interactive digital environment is accessed, where the interactive digital environment is a shared digital environment for a plurality of participants. The participants include presenters and viewers. A plurality of images is obtained from a first set of participants within the plurality of participants involved in the interactive digital environment. Cognitive state content is analyzed within the plurality of images for the first set of participants within the plurality of participants. Results of the analyzing cognitive state content are provided to a second set of participants within the plurality of participants. The obtaining and the analyzing are accomplished on a device local to a participant such that images of the first set of participants are not transmitted to a non-local device. The analyzing cognitive state content is augmented with evaluation of audio information.

Abstract: A control system configured to control manipulation of a surgical instrument in response to manipulation of a remote surgeon input device, the surgical instrument comprising opposable first and second end effector elements connected to a shaft by an articulated coupling, the articulated coupling comprising a first joint driveable by a first pair of driving elements so as to permit the first end effector element to rotate, and a second joint driveable by a second pair of driving elements so as to permit the second end effector element to rotate, the control system configured to: detect a change of configuration of the surgeon input device to a gripping configuration at time t; respond to the change of configuration of the surgeon input device to the gripping configuration by commanding gripping forces to be applied to the first and second pairs of driving elements, so as to cause the first and second end effector elements to rotate in opposing rotational directions towards each other with a gripping closing fo

Abstract: A control system for a surgical robotic system, the surgical robotic system comprising a remote surgeon console and an articulated surgical robot arm comprising a series of joints extending from a base to a terminal end for attaching to an articulated surgical instrument. The control system comprises a central controller communicatively coupled to and remotely located from an arm controller of the surgical robot arm, the central controller also communicatively coupled to a surgeon input device of the surgeon console.

Abstract: A control system configured to control manipulation of a surgical instrument in response to manipulation of a remote surgeon input device. The surgical instrument comprises opposable first and second end effector elements connected to a shaft by an articulated coupling. The articulated coupling comprises a first joint driveable by a first pair of driving elements so as to permit the first end effector element to rotate, and a second joint driveable by a second pair of driving elements so as to permit the second end effector element to rotate.

Abstract: There is provided a phospholipid composition which is a bilayer or micelle comprising at least one embedded protein-polymer surfactant conjugate comprising an anchor protein, wherein the anchor protein is a cationised protein or an anionised protein, the composition characterised in that the anchor protein is: a) an active enzyme; or b) is a protein which does not comprise a —CH2C(O)NCH3(CH2)3NCH3)2H+ linker covalently bonded to an amino acid side chain.

Abstract: A control system for controlling manipulation of a surgical instrument in response to manipulation of a remote surgeon input device. The surgical instrument comprises opposable first and second end effector elements connected to a shaft by an articulated coupling.

Abstract: Data on a user interacting with a media presentation is collected at a client device. The data includes facial image data of the user. The facial image data is analyzed to extract cognitive state content of the user. One or more emotional intensity metrics are generated. The metrics are based on the cognitive state content. The media presentation is manipulated, based on the emotional intensity metrics and the cognitive state content. An engagement score for the media presentation is provided. The engagement score is based on the emotional intensity metric. A facial expression metric and a cognitive state metric are generated for the user. The manipulating includes optimization of the previously viewed media presentation. The optimization changes various aspects of the media presentation, including the length of different portions of the media presentation, the overall length of the media presentation, character selection, music selection, advertisement placement, and brand reveal time.

Abstract: The present invention relates to receptor tyrosine kinase-like orphan receptor 1 (ROR1) specific antigen binding molecules and associated fusion proteins and conjugates. In a further aspect, the present invention relates to conjugated immunoglobulin-like shark variable novel antigen receptors (VNARs).

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Accordingly, these compounds can be used as modulators of TNF. Anew assay for identifying compounds with this mechanism of action is also disclosed.