Patents by Inventor Graham John Durant

Graham John Durant has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazolylmethylthio-ethyl isothiourea compounds
    Patent number: 4120972
    Abstract: The compounds are dithiocarbamates and isothioureas which are histamine H.sub.2 -antagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolylmethylthio)ethyl]-N-cyano-N'-methylisothiourea.
    Type: Grant
    Filed: August 11, 1977
    Date of Patent: October 17, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Heterocyclic-methylthioethyl-dithiocarbamates and isothioureas
    Patent number: 4120966
    Abstract: The compounds are dithiocarbamates and isothioureas which are histamine H.sub.2 -anatagonists. Two compounds of the invention are 2-(5-methyl-4-imidazolylmethylthio)ethyl N-methyldithiocarbamate and S-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]-N-cyano-N'-methylisothiourea .
    Type: Grant
    Filed: August 11, 1977
    Date of Patent: October 17, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Amidinoformic and amidino-sulphinic acid derivatives
    Patent number: 4118502
    Abstract: Amidinoformic acids and amidinosulphinic acids which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-[2-(5-methyl-4-imidazolylmethylthio)-ethyl]amidinoformic acid and N-methyl-N'-[2-(5-methyl-4-imidazolylmethylthio)ethyl]amidinosulphinic acid.
    Type: Grant
    Filed: March 2, 1977
    Date of Patent: October 3, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Heterocyclic-methylthioalkyl-amidines
    Patent number: 4118496
    Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkyl-isothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolyl-methylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: October 3, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Pharmacologically active compounds
    Patent number: 4112104
    Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. Two compounds of this invention are N,N'-bis[2-((4-methyl-5-imidazolyl)methylthio)ethyl]thiourea and N,N'-bis]2-((4-methyl-5-imidazoly)methylthio)ethyl]-N"-cyanoguanidine.
    Type: Grant
    Filed: February 22, 1977
    Date of Patent: September 5, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin
  • Pharmacologically active compounds
    Patent number: 4109003
    Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: August 22, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Pharmacologically active compounds
    Patent number: 4107319
    Abstract: The compounds are N-(heterocyclomethylthioalkyl)derivatives of alkylguanidines, C-alkyl and C-aryl amidines and S-alkylisothioureas. The compounds may also have N'-lower alkyl or N'-(heterocyclomethylthioalkyl)substituents. Three compounds of the invention are S-methyl-N-[2-(5-methyl-4-imidazolylmethylthio)ethyl]isothiourea, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]acetamidine, N,N'-bis-[2-(5-methyl-4-imidazolylmethylthio)ethyl]N"-methylguanidine. The compounds of this invention are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 5, 1977
    Date of Patent: August 15, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Rodney Christopher Young
  • Pharmacologically active compounds
    Patent number: 4104381
    Abstract: Heterocyclic compounds which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A specific compound of this invention is 2-[2-(4-methyl-5-imidazolylmethylthio)ethylamino]-4-pyrimidone.
    Type: Grant
    Filed: October 29, 1976
    Date of Patent: August 1, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Imidazolyl alkylguanidine compounds
    Patent number: 4098898
    Abstract: The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: May 13, 1976
    Date of Patent: July 4, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Geoffrey Robert Owen, Rodney Christopher Young
  • Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas
    Patent number: 4093621
    Abstract: Process for preparing heterocyclicalkylthioalkyl-N-cyanoguanidines and thioureas by treating a heterocyclicalkyl derivative with a mercaptoalkyl-N-cyanoguanidine or thiourea. Two specific products are N-cyano-N'-methyl-N"-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]guanidine and N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea, both useful as histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: November 15, 1976
    Date of Patent: June 6, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Thomas Henry Brown, Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • N-Oxy and N-amino guanidines
    Patent number: 4093729
    Abstract: The compounds are N-oxy and N-amino guanidines which are histamine H.sub.2 -antagonists. A compound of this invention is N-hydroxy-N'-methyl-N"-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]guanidi ne.
    Type: Grant
    Filed: April 11, 1977
    Date of Patent: June 6, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Geoffrey Robert Owen
  • Certain nitrogen heterocyclic isothiocyanate esters
    Patent number: 4090026
    Abstract: Process for preparing thioureas by treating isothiocyanates with ammonia and alkylamines. A specific product is N-methyl-N'-[2-((5-methyl-4-imidazolyl)methylthio)ethyl]thiourea, useful as a histamine H.sub.2 -antagonist.
    Type: Grant
    Filed: August 13, 1976
    Date of Patent: May 16, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, George Raymond White
  • Pharmacologically active compounds
    Patent number: 4083988
    Abstract: The compounds are guanidines, for example N-benzenesulphonyl-N'-[2-((4-methyl-5-imidazolyl)-methylthio)ethyl]guanidi ne, which are inhibitors of histamine activity.
    Type: Grant
    Filed: September 24, 1976
    Date of Patent: April 11, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pharmacologically active compounds
    Patent number: 4084001
    Abstract: The compounds are substituted S-(aminoalkyl)isothioureas which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are S-[6-(N'-methylthioureido)hexyl]isothiourea and S-[5-(N'-cyano-N"-methylguanidino)pentyl]isothiourea.
    Type: Grant
    Filed: November 23, 1976
    Date of Patent: April 11, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, Robert John Ife
  • Alkoxy pyridine compounds
    Patent number: 4083983
    Abstract: The compounds are alkoxypyridine compounds which are histamine H.sub.2 -antagonists. Two specific compounds of the present invention are N-cyano-N'-methyl-N"-[2-((3-methoxy-2-pyridyl)methylthio)ethyl]guanidine and 1-methylamino-1-[2-(3-methoxy-2-pyridyl)methylthio)ethylamino]-2-nitroethy lene.
    Type: Grant
    Filed: July 13, 1976
    Date of Patent: April 11, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin, George Sidney Sach
  • Pyridyl-alkylaminoethylene compounds
    Patent number: 4080459
    Abstract: The compounds are ethylene derivatives which are inhibitors of histamine activity, in particular, inhibitors of H-2 histamine receptors. A compound of this invention is 1-nitro-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]2-[2-((3-chloro -2-pyridyl)methylthio)ethylamino]ethylene.
    Type: Grant
    Filed: November 19, 1976
    Date of Patent: March 21, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin, Hunter Douglas Prain
  • Guanidino, thioureido, isothioureido and nitrovinylamino derivatives of pyridine
    Patent number: 4070472
    Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N',N"-disubstituted guanidino), N-(N'-substituted thioureido), N-(nitromethylene amidino) or S-(N-substituted isothioureido)groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: April 20, 1976
    Date of Patent: January 24, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin
  • Pharmacologically active guanidine compounds as H-2 histamine receptor inhibitors
    Patent number: 4070475
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl-, and oxyalkyl-guanidines which are inhibitors of histamine activity.
    Type: Grant
    Filed: February 2, 1977
    Date of Patent: January 24, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Pharmacologically active thiourea and urea compounds as inhibitors of H-2 histamine receptors
    Patent number: 4069327
    Abstract: The compounds are substituted thioalkyl-, aminoalkyl- and oxyalkyl-thioureas and ureas which are inhibitors of histamine activity.
    Type: Grant
    Filed: January 5, 1977
    Date of Patent: January 17, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, John Colin Emmett, Charon Robin Ganellin
  • Guanidino, thioureido and isothioureido derivatives containing imidazole groups
    Patent number: RE29761
    Abstract: The compounds are C.sub.2 -C.sub.8 straight chain alkanes terminally substituted, symmetrically or unsymmetrically, by N-(N'-substituted guanidino), N-(N', N"-disubstituted guanidino), N-(N'-substituted thiouredo), N-(nitromethylene amidino) or S-(N-substituted isothioureido) groups. Two compounds of the invention are 1,3-bis-[N'-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidino]propane and 1,3-bis-[S-(N-2-(5-methyl-4-imidazolylmethylthio)ethyl)isothioureido]p ropane. The compounds of this invention are inhibitors of H-2 histamine receptors.
    Type: Grant
    Filed: October 19, 1977
    Date of Patent: September 12, 1978
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham John Durant, Charon Robin Ganellin