Patents by Inventor Graham Lidgard

Graham Lidgard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Normalization of polymerase activity
    Patent number: 11708603
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: February 11, 2021
    Date of Patent: July 25, 2023
    Assignee: Exact Sciences Corporation
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20210189462
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: February 11, 2021
    Publication date: June 24, 2021
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Normalization of polymerase activity
    Patent number: 10954556
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: September 18, 2018
    Date of Patent: March 23, 2021
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20190153510
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: September 18, 2018
    Publication date: May 23, 2019
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Normalization of polymerase activity
    Patent number: 10106844
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: November 12, 2015
    Date of Patent: October 23, 2018
    Assignee: Exact Sciences Development Company, LLC
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Methods for quantifying nucleic acid variations
    Patent number: 9710596
    Abstract: Provided herein is technology relating to evaluating the state of nucleic acids and particularly, but not exclusively, to methods for measuring variations between DNAs, including differences in methylation and mutation.
    Type: Grant
    Filed: November 21, 2012
    Date of Patent: July 18, 2017
    Assignee: EXACT SCIENCES CORPORATION
    Inventor: Graham Lidgard
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20160060683
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: November 12, 2015
    Publication date: March 3, 2016
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Hand-held scanner systems and methods for reading point of care test results
    Patent number: 9222875
    Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
    Type: Grant
    Filed: December 18, 2013
    Date of Patent: December 29, 2015
    Assignee: Nexus Dx, Inc.
    Inventors: Richard Egan, Graham Lidgard, David Booker
  • Normalization of polymerase activity
    Patent number: 9212392
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Grant
    Filed: September 25, 2013
    Date of Patent: December 15, 2015
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Sample collection device
    Patent number: 8960026
    Abstract: Provided herein is technology relating to collecting samples of soft matter compositions, and particularly, but not exclusively, to devices and methods for collecting stool samples.
    Type: Grant
    Filed: April 18, 2012
    Date of Patent: February 24, 2015
    Assignee: Exact Sciences Corporation
    Inventors: Hemanth Shenoi, Mike Domanico, Graham Lidgard, Joseph E. Schiestle, Scott Castanon, Keith Kopitzke, Martin Bouliane
  • HAND-HELD SCANNER SYSTEMS AND METHODS FOR READING POINT OF CARE TEST RESULTS
    Publication number: 20140343860
    Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
    Type: Application
    Filed: December 18, 2013
    Publication date: November 20, 2014
    Inventors: Richard EGAN, Graham LIDGARD, David BOOKER
  • NORMALIZATION OF POLYMERASE ACTIVITY
    Publication number: 20140087382
    Abstract: Provided herein is technology relating to the amplification-based detection of nucleic acids and particularly, but not exclusively, to methods and compositions for minimizing variability in the activity between different samples or manufacturing lots of DNA polymerases, such as Taq DNA polymerase.
    Type: Application
    Filed: September 25, 2013
    Publication date: March 27, 2014
    Applicant: Exact Sciences Corporation
    Inventors: Hatim Allawi, Rebecca Oldham-Haltom, Zubin Gagrat, Michael Domanico, Graham Lidgard
  • Hand-held scanner systems and methods for reading point of care test results
    Patent number: 8638441
    Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
    Type: Grant
    Filed: April 7, 2010
    Date of Patent: January 28, 2014
    Assignee: Nexus Dx, Inc.
    Inventors: Richard Egan, Graham Lidgard, David Booker
  • SAMPLE COLLECTION DEVICE
    Publication number: 20120260748
    Abstract: Provided herein is technology relating to collecting samples of soft matter compositions, and particularly, but not exclusively, to devices and methods for collecting stool samples.
    Type: Application
    Filed: April 18, 2012
    Publication date: October 18, 2012
    Applicant: EXACT SCIENCES CORPORATION
    Inventors: Hemanth Shenoi, Mike Domanico, Graham Lidgard, Joseph E. Schiestle, Scott Castanon, Keith Kopitzke, Martin Bouliane
  • HAND-HELD SCANNER SYSTEMS AND METHODS FOR READING POINT OF CARE TEST RESULTS
    Publication number: 20100315644
    Abstract: A diagnostic assay system including a test device and a scanning device are described. In one implementation, the scanning device includes a source of electromagnetic radiation, an optics assembly, a detector, and a microprocessor disposed within a chassis. The test device and scanning device may be configured to be movable relative to each other during operation of the scanning device.
    Type: Application
    Filed: April 7, 2010
    Publication date: December 16, 2010
    Applicant: NEXUS DX, INC.
    Inventors: Richard Egan, Graham Lidgard, David Booker
  • METHOD FOR GENERATING TARGET NUCLEIC ACID SEQUENCES
    Publication number: 20090092967
    Abstract: The present invention provides methods of generating target nucleic acids for amplification using nicking enzymes and methods for amplifying the generated target nucleic acids.
    Type: Application
    Filed: June 26, 2007
    Publication date: April 9, 2009
    Applicant: Epoch Biosciences, Inc.
    Inventors: Zuxu Yao, Graham Lidgard, Yevgeniy Belousov
  • Method for Detecting Large Mutations and Duplications Using Control Amplification Comparisons to Paralogous Genes
    Publication number: 20090087846
    Abstract: Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.
    Type: Application
    Filed: May 9, 2008
    Publication date: April 2, 2009
    Inventors: Ray R. Radtkey, Douglas Whitman, Graham Lidgard
  • Methods for Rapid, Single-Step Strand Displacement Amplification of Nucleic Acids
    Publication number: 20080096257
    Abstract: A single-step, isothermal strand displacement amplification method that is conducted without the requirement for heat denaturation of the target nucleic acid. The method is particularly useful for analysis of clinical samples due to the decreased risk of potential contamination of the patient sample.
    Type: Application
    Filed: August 13, 2007
    Publication date: April 24, 2008
    Inventors: Zuxu Yao, Graham Lidgard
  • Method for detecting large mutations and duplications using control amplification comparisons to paralogous genes
    Publication number: 20070020671
    Abstract: Methods for querying biological samples to detect genetic mutations, particularly insertions and deletions, by co-amplification of a gene of interest in conjunction with a paralogous gene. When the gene of interest and the corresponding paralogous gene are selected from the CYP450 family, the resulting ratios may predict how a particular patient metabolizes certain prescription drugs.
    Type: Application
    Filed: July 12, 2006
    Publication date: January 25, 2007
    Inventors: Ray Radtkey, Douglas Whitman, Graham Lidgard
  • Nuclear matrix protein fluid assay
    Publication number: 20060127941
    Abstract: Disclosed is a method for detecting and quantitating soluble nuclear matrix proteins in body fluids and extracellular media. The method is useful for monitoring the viability of cells and tissue, for evaluating the progress of a disease or its treatment, and for evaluating the cytotoxicity of unknown compounds. Also disclosed are methods for inducing the release of nuclear matrix proteins in soluble form from cells.
    Type: Application
    Filed: February 2, 2006
    Publication date: June 15, 2006
    Applicant: Matritech, Inc.
    Inventors: Lee Beausang, Graham Lidgard, Thomas Miller