Patents by Inventor Graham McClorey

Graham McClorey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LINKERS
    Publication number: 20220125934
    Abstract: The present invention relates to linkers for connecting a carrier molecule to a therapeutic molecule to form a conjugate, in particular linkers formed of amino acids such as glutamic acid, succinic acid, and gamma-aminobutyric acid. The present invention further relates to a conjugate comprising a linker of the invention, and the use of said conjugate in the treatment of various diseases.
    Type: Application
    Filed: December 6, 2019
    Publication date: April 28, 2022
    Inventors: Richard Raz, Matthew Wood, Caroline Godfrey, Graham McClorey, Subhashis Banerjee, Michael Gait, Miguel Varela, Ashling Holland
  • CELL PENETRATING MOLECULE
    Publication number: 20220090066
    Abstract: The present invention relates to cell penetrating molecules comprising two oligonucleotide cargo molecules.
    Type: Application
    Filed: November 22, 2020
    Publication date: March 24, 2022
    Inventors: Matthew Wood, Graham McClorey, Michael Gait, Peter Jarver, Amer Salah, Fazel Shabanpoor
  • CELL PENETRATING PEPTIDES
    Publication number: 20220041662
    Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system.
    Type: Application
    Filed: April 23, 2021
    Publication date: February 10, 2022
    Applicants: Oxford University Innovation Limited, United Kingdom Research and Innovation
    Inventors: Matthew Wood, Suzan Hammond, Melissa Bowerman, Michael Gait, Frank Adendroth, Graham McClorey
  • CELL-PENETRATING PEPTIDES
    Publication number: 20210299263
    Abstract: The present invention relates to peptides, in particular cell-penetrating peptides, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.
    Type: Application
    Filed: August 9, 2019
    Publication date: September 30, 2021
    Inventors: Matthew Wood, Raquel Manzano, Caroline Godfrey, Graham McClorey, Richard Raz, Michael Gait, Andrey Arzumanov, Liz O'Donovan, Gareth Hazell, Ashling Holland, Miguel Varela
  • CELL-PENETRATING PEPTIDES
    Publication number: 20210299264
    Abstract: the present invention relates to peptides, in particular cell-penetrating peptides, having a first hydrophobic domain positioned at the C-terminus of the peptide and a second hydrophobic domain positioned at the N-terminus of the peptide, and to conjugates of such cell-penetrating peptides with a therapeutic molecule. The present invention further relates to use of such peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders and in particular muscular dystrophies such as Duchenne muscular dystrophy.
    Type: Application
    Filed: August 9, 2019
    Publication date: September 30, 2021
    Inventors: Matthew Wood, Samir El Andaloussi, Graham McClorey, Raquel Manzano, Michael J. Gait, Caroline Godfrey, Andrey Arzumanov, Liz O'Donovan, Richard Raz
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20210198666
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Application
    Filed: August 19, 2020
    Publication date: July 1, 2021
    Applicant: The University of Western Australia
    Inventors: Stephen Donald WILTON, Sue FLETCHER, Graham MCCLOREY
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 10995337
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Grant
    Filed: May 22, 2020
    Date of Patent: May 4, 2021
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 10968450
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Grant
    Filed: July 31, 2019
    Date of Patent: April 6, 2021
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 10781451
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: September 22, 2020
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20200283772
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Application
    Filed: May 22, 2020
    Publication date: September 10, 2020
    Applicant: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20200199590
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Application
    Filed: July 31, 2019
    Publication date: June 25, 2020
    Applicant: The University of Western Australia
    Inventors: Stephen Donald WILTON, Sue FLETCHER, Graham MCCLOREY
  • CELL PENETRATING PEPTIDES
    Publication number: 20200131231
    Abstract: The present invention relates to peptides, in particular cell penetrating peptides, of 40 amino acid residues or less comprising at least one directly glycosylated amino residue and one or more arginine rich arm domains, and to conjugates of such cell penetrating peptides with a therapeutic molecule. The present invention further relates to the use of the peptides or conjugates in methods of treatment or as a medicament, especially in the treatment of genetic disorders of the central nervous system. page.
    Type: Application
    Filed: February 16, 2018
    Publication date: April 30, 2020
    Inventors: Matthew Wood, Suzan Hammond, Melissa Bowerman, Michael Gait, Frank Adendroth, Graham McClorey
  • Combined therapy for duchenne muscular dystrophy
    Patent number: 10471089
    Abstract: The present invention relates to the combined use of antisense oligonucleotides and viral vectors for the treatment of Duchenne muscular dystrophy.
    Type: Grant
    Filed: June 10, 2016
    Date of Patent: November 12, 2019
    Assignees: ASSOCIATION INSTITUT DE MYOLOGIE, SORBONNE UNIVERSITE, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
    Inventors: Stephanie Lorain, Thomas Voit, Matthew Wood, Graham McClorey
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20190323010
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Application
    Filed: July 1, 2019
    Publication date: October 24, 2019
    Applicant: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: 10421966
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Grant
    Filed: January 22, 2019
    Date of Patent: September 24, 2019
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • ANTISENSE OLIGONUCLEOTIDES FOR INDUCING EXON SKIPPING AND METHODS OF USE THEREOF
    Publication number: 20190144861
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 214.
    Type: Application
    Filed: January 22, 2019
    Publication date: May 16, 2019
    Applicant: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: RE47691
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: July 10, 2017
    Date of Patent: November 5, 2019
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: RE47751
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: July 20, 2017
    Date of Patent: December 3, 2019
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: RE47769
    Abstract: Antisense molecules capable of binding to a selected target site in the dystrophin gene to induce exon skipping are described.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: December 17, 2019
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey
  • Antisense oligonucleotides for inducing exon skipping and methods of use thereof
    Patent number: RE48960
    Abstract: An antisense molecule capable of binding to a selected target site to induce exon skipping in the dystrophin gene, as set forth in SEQ ID NO: 1 to 202.
    Type: Grant
    Filed: December 19, 2019
    Date of Patent: March 8, 2022
    Assignee: The University of Western Australia
    Inventors: Stephen Donald Wilton, Sue Fletcher, Graham McClorey