Patents by Inventor Graham McCreath

Graham McCreath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Fibrinogen from transgenic animals
    Publication number: 20070219352
    Abstract: The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase with the removal or partition of fibrinogen into another phase of the milk. The present invention also provides a method for obtaining fibrinogen from a fluid, the method comprising: a) contacting the fluid with a hydrophobic interaction chromatography resin under conditions where the fibrinogen binds to the resin; and b) removing the bound protein by means of elution.
    Type: Application
    Filed: April 9, 2007
    Publication date: September 20, 2007
    Applicant: Pharming Intellectual Property BV
    Inventors: Graham McCreath, Michael Udell
  • Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography
    Patent number: 7211650
    Abstract: The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase with the removal or partition if fibrinogen into another phase of the milk. The present invention also provides a method for obtaining fibrinogen from a fluid, the method comprising: a) contacting the fluid with a hydrophobic interaction chromatography resin under conditions where the fibrinogen binds to the resin; and b) removing the bound protein by means of elution.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: May 1, 2007
    Assignee: Pharming Intellectual Property BV
    Inventors: Graham McCreath, Udell Michael
  • Purification of fibrinogen from milk by use of cation exchange chromatography
    Patent number: 6740736
    Abstract: Fibrinogen is obtained from milk by contact with a cation exchange chromatography substrate under conditions where the fibrinogen binds to the substrate, followed by optional washing of the substrate. The bound fibrinogen is removed from the substrate by irrigation under increased ionic strength or increased pH conditions. The obtained fibrinogen may be naturally produced or transgenic.
    Type: Grant
    Filed: March 22, 2001
    Date of Patent: May 25, 2004
    Assignee: PPL Therapeutics (Scotland) Limited
    Inventor: Graham McCreath
  • Purification of fibrinogen from milk by use of cation exchange chromatography
    Publication number: 20020025932
    Abstract: Fibrinogen is obtained from milk by contact with a cation exchange chromatography substrate under conditions where the fibrinogen binds to the substrate, followed by optional washing of the substrate. The bound fibrinogen is removed from the substrate by irrigation under increased ionic strength or increased pH conditions. The obtained fibrinogen may be naturally produced or transgenic.
    Type: Application
    Filed: March 22, 2001
    Publication date: February 28, 2002
    Inventor: Graham McCreath
  • Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography
    Publication number: 20020019025
    Abstract: The present invention provides a method for the part purification of fibrinogen from milk, the method comprising the transfer of protease enzyme which is present in the milk, into the whey phase with the removal or partition if fibrinogen into another phase of the milk. The present invention also provides a method for obtaining fibrinogen from a fluid, the method comprising: a) contacting the fluid with a hydrophobic interaction chromatography resin under conditions where the fibrinogen binds to the resin; and b) removing the bound protein by means of elution.
    Type: Application
    Filed: March 22, 2001
    Publication date: February 14, 2002
    Inventors: Graham McCreath, Udell N. Michael