Abstract: An inhaler for inhalation of an inhalable dry powder is provided. The inhaler has (a) an outer shell having a first shell part and a second shell part; (b) a capsule holder having a chamber for holding a capsule, a capsule breaker for breaking open a capsule held within the chamber and a trigger for causing the capsule breaker to break open a capsule; (c) a support for supporting the capsule holder; and (d) an outlet for passage of dry powder from the capsule into a user. The capsule holder is positioned in the first shell part which has an aperture through which the trigger protrudes. The aperture has a cut-out in the rim of the first shell part and through which the trigger may pass when the capsule holder is removed from the first shell part.

Abstract: Described herein is an inhaler for inhalation of an inhalable dry powder. The inhaler comprises (a) an outer shell comprising a first shell part and a second shell part; (b) a capsule holder comprising a chamber for holding a capsule, a capsule breaker for breaking open a capsule held within the chamber and a trigger for causing the capsule breaker to break open a capsule; (c) a support for supporting the capsule holder; and (d) an outlet for passage of dry powder from the capsule into a user. The capsule holder is positioned in the first shell part which comprises an aperture through which the trigger protrudes. The aperture comprises a cut-out in the rim of the first shell part and through which the trigger may pass when the capsule holder is removed from the first shell part.

Abstract: An inhalation device comprising a hermetically sealed receptacle (1) containing a single dose of a pressurized formulation (30) comprising a pharmaceutically active ingredient and a liquefied aerosol propellant consisting of HFA 134a, HFA 227 or a mixture thereof and wherein at least a portion (12) of the receptacle is perforable.

Abstract: A valve stem (100) for use with a metered dose dispensing valve, said valve stem having a central longitudinal axis and comprising a first stem portion (101), a second stem portion (102) and a disk seal (112), said disk seal being disposed between the first and second stem portion along the longitudinal axis of the valve stem and said disk seal extending radially outwardly from the central longitudinal axis of valve stem so as to be capable of forming a fluid-tight seal with a portion of an internal wall of said valve.

Abstract: A dose counter for use with an inhaler comprising a container for medicament equipped with a reciprocal actuation means to dispense a dose of medicament therefrom, the dose counter comprising: a fixed ratchet member, a trigger member constructed and arranged to undergo reciprocal movement coordinated with the reciprocal movement between the actuation means and the container, said reciprocal movement comprising an outward stroke and a return stroke, a counter member constructed and arranged to undergo a predetermined counting movement each time a dose is dispensed, the counter member being biased towards the ratchet and trigger members and being capable of counting motion in a direction generally orthogonal to the direction of reciprocal movement of the trigger member, the counter member comprising: a first region for interaction with the trigger member which comprises at least one inclined surface which is engaged by the trigger member during its outward stroke causing the counter member to undergo counting m

Abstract: A valve stem for use with a metering valve, said valve stem comprising an elongate stem element and a sealing element arranged onto the elongate stem element, wherein the sealing element is co-molded with at least a portion of the elongate stem element and the elongate stem element is made of a material comprising a polymer selected from the group consisting of polyaryletherketones, thermotropic liquid crystalline polymers, polymethylpentene, polyphenylene sulfide and mixtures thereof; as well as methods of manufacturing such a valve stem.