Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).

Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).

Abstract: A system for tracking position and identification of a moving element on a conveyor system having a track, the system including: a machine readable medium provided to one of the moving element or the track, wherein the machine readable medium is configured with at least two channels with a predetermined phase difference therebetween; a sensor provided to the other of the moving element or the track, wherein the sensor is configured to read the at least two channels; and a controller configured to receive data from the sensor and determine a position and/or identification of the moving element on the track based on the phase difference.

Abstract: A method for producing a customized surgical instrument or prosthesis for a specific patient is described. At least one x-ray image of a body part of the patient is captured. A statistical model having a dense set of anatomical correspondence points across the model is instantiated using image data derived from the at least one x-ray image to generate a patient specific model of the body part having a high accuracy surface. Patient specific data from the patient specific model is used to generate a design of the customized surgical instrument or prosthesis for use in a surgical procedure to be carried out on the body part. The surgical instrument or prosthesis is then manufactured using the design. A computer implemented method for generating the patient specific model of the body part is also described.

Abstract: This claimed subject matter relates to techniques for generating. a test script from a pre-existing script for testing a graphical user interlace (GUI) comprising: parsing a pre-existing test script; parsing the model associated with the GUI; identifying GUI actions that that are identified by keywords and associated parameters that exist in the pre-existing test script; and generating a new test script by adding the identified actions.

Abstract: This claimed subject matter relates to techniques for generating a test script from a pre-existing script for testing a graphical user interface (GUI) comprising: parsing a pre-existing test script; parsing the model associated with the GUI; identifying GUI actions that are identified by keywords and associated parameters that exist in the pre-existing test script; and generating a new test script by adding the identified actions.

Abstract: A computer-implemented method of generating a model that models a class of objects. The method comprises, for each of a plurality of objects of the class of objects, receiving a first two-dimensional image of the object and first acquisition data, receiving a second two-dimensional image of the object and second acquisition data and receiving data indicating a plurality of points of interest within the object. The first and second two-dimensional images are combined based upon the first and second acquisition data to generate three-dimensional image data, the three-dimensional image data including data based upon the data indicating a plurality of points of interest and the generated three-dimensional image data for each of the objects of the class of objects is processed to generate the model.

Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).

Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).

Abstract: A PCD cutting element for use in earth boring drill bits where die interstices remote from the working surface are filled with a catalyzing material and the interstices adjacent to the working surface are substantially free of the catalyzing material is described. An intermediate region between the substantially free portion and filled portion has a plurality of generally conically sectioned catalyst-free projections which taper down, extending to a second depth from the planar working surface, preferably about 0.5 times or more of the first depth.

Abstract: The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.

Abstract: The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.

Abstract: A computer-implemented method of generating a model that models a class of objects. The method comprises, for each of a plurality of objects of the class of objects, receiving a first two-dimensional image of the object and first acquisition data, receiving a second two-dimensional image of the object and second acquisition data and receiving data indicating a plurality of points of interest within the object. The first and second two-dimensional images are combined based upon the first and second acquisition data to generate three-dimensional image data, the three-dimensional image data including data based upon the data indicating a plurality of points of interest and the generated three-dimensional image data for each of the objects of the class of objects is processed to generate the model.

Abstract: A rod antenna and antenna circuit are described which make use of negative feedback to reduce the Q of the antenna, but which also makes use of a different coil tapping arrangement to significantly reduce electric field susceptibility on the detected signal from the main coil as well as different biasing arrangements to reduce noise. More particularly, in some embodiments of the invention the main detector coil of the antenna has a centre tap that is AC grounded with signal taps then being taken from the opposite ends of the main coil, and being respectively fed to the inputs of a differential amplifier. The output of the differential amplifier is then fed to the magnetic circuit of the rod antenna via a second inductor winding that is magnetically coupled to the resonance circuit of the main antenna coil.

Abstract: The present invention relates to compounds and processes for preparing compounds of Formula (I), including compounds such as trans-7-oxo-6-(sulphooxy)-1,6-diazabicyclo[3,2,1]octane-2-carboxamide and salts thereof (e.g., NXL-104).

Abstract: The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.

Abstract: The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.

Abstract: The invention is directed to a method of inhibiting bone resorption. The method comprises administering to a human an amount of sclerostin inhibitor that reduces a bone resorption marker level for at least 2 weeks. The invention also provides a method of monitoring anti-sclerostin therapy comprising measuring one or more bone resorption marker levels, administering a sclerostin binding agent, then measuring the bone resorption marker levels. Also provided is a method of increasing bone mineral density; a method of ameliorating the effects of an osteoclast-related disorder; a method of treating a bone-related disorder by maintaining bone density; and a method of treating a bone-related disorder in a human suffering from or at risk of hypocalcemia or hypercalcemia, a human in which treatment with a parathyroid hormone or analog thereof is contraindicated, or a human in which treatment with a bisphosphonate is contraindicated.