Abstract: A dropout insert which may be used in combination with a replacement axle and a bolt to convert a multi-gear bicycle having either a SRAM universal derailleur hanger or SRAM T-type transmission into a single gear bicycle.

Abstract: A method of improving diagnosis, prognosis, or treatment includes accessing a digital health record, identifying, from the digital health record, an entry in which a replacement string or an additional string is to be suggested, determining a particular string to suggest as a replacement or addition to existing text in the entry, in response to suggesting the particular string, presenting a source of the particular string and one or more alternatives to the particular string, receiving an input indicating whether the particular string or the one or more alternatives are accepted, updating the entry based on the received input, and determining a medical diagnosis, prognosis, or treatment according to the updated entry. This method may provide diagnosis, prognosis, or treatment for COVID-19 patients.

Abstract: A method of improving diagnosis, prognosis, or treatment includes accessing a digital health record, identifying, from the digital health record, an entry in which a replacement string or an additional string is to be suggested, determining a particular string to suggest as a replacement or addition to existing text in the entry, in response to suggesting the particular string, presenting a source of the particular string and one or more alternatives to the particular string, receiving an input indicating whether the particular string or the one or more alternatives are accepted, updating the entry based on the received input, and determining a medical diagnosis, prognosis, or treatment according to the updated entry. This method may provide diagnosis, prognosis, or treatment for COVID-19 patients.

Abstract: Provided are systems and methods that assist medical professionals, healthcare providers, patients and other users to identify medical calculators suitable for diagnosis, prognosis or treatment. Once identified, the systems and methods also facilitate the use of the calculator by the user with appropriate instructions and references, and recommendations to other potentially useful and relevant calculators.

Abstract: A device includes a first power over Ethernet (POE) port and a second POE port. One of the first POE port and the second POE port is configured as a primary port to supply power and another one of the first POE port and the second POE is configured as a redundant port to supply power. The supply of power through the primary POE port is disabled and supply of power through the redundant POE port is enabled responsive to the supply of power through the primary POE port being non-conformant with a given standard.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of the general formula And their use in the treatment of psychotic disorders and cognitive impairment are disclosed.

Abstract: Compounds of general formula and their use in the treatment of psychotic disorders and cognitive impairment, are disclosed.

Abstract: Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I), salts and solvates are provided: Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: Compounds of formula (I), salts and solvates are provided, Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: Compounds of formula (I), salts and solvates are provided: Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein Uses of the compounds for the treatment of psychotic disorders and cognitive mpairment, are also disclosed.

Abstract: The present invention is directed to a method and system for providing redundancy and resiliency features to network devices, such as switches and routers, that do not have built-in redundancy and resiliency features. Health-check messages are periodically transmitted over a first link that transmits network data. Upon detecting a failure of the first link, transmission of network data is switched to a second redundant link, while health check messages continue to be periodically transmitted over the first link. Upon detecting that the first link has been restored, transmission of network data is switched to the first link.

Abstract: The invention provides compounds of the formula or a pharmaceutically acceptable salts thereof. The compounds are useful in therapy, in particular as antipsychotic agents.

Abstract: Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: The present invention is directed to a much safer and less expensive way of providing portable oxygen from a gas concentrator for patients who do not want to be tied to a stationary machine or restricted by present oxygen technology. The present invention involves a home liquid oxygen ambulatory system for supplying a portable supply of oxygen, where a portion of the gaseous oxygen output obtained from an oxygen concentrator is condensed into liquid oxygen. The system includes an oxygen concentrator which separates oxygen gas from the ambient air, a condenser in communication with the oxygen concentrator for receiving and liquefying the oxygen gas flow, a cryocooler associated with the condenser, and a first storage dewar in fluid communication with the condenser and adapted to store the oxygen liquefied by the condenser, the first storage dewar including means for transferring liquid oxygen from the first dewar to a second dewar for storing a quantity of oxygen suitable for moveable oxygen treatment.