Abstract: A refrigeration system includes a compressor having a hermetically sealed housing and a compression mechanism which is positioned inside the housing; a condenser which is fluidly connected to the compressor; an evaporator which is fluidly connected between the condenser and the compressor; a magnetic coupling having a drive coupling half positioned outside the housing and a driven coupling half positioned inside the housing and separated from the drive coupling half by a separation wall portion of the housing; and a fluid conduit for communicating a portion of liquid refrigerant from the condenser to an inside surface of the separation wall portion. During operation, the liquid refrigerant from the condenser is evaporated on or adjacent the inside surface of the separation wall portion to thereby dissipate heat generated by magnetically induced eddy currents in the separation wall portion.

Abstract: A refrigeration system includes a compressor having a hermetically sealed housing and a compression mechanism which is positioned inside the housing; a condenser which is fluidly connected to the compressor; an evaporator which is fluidly connected between the condenser and the compressor; a magnetic coupling having a drive coupling half positioned outside the housing and a driven coupling half positioned inside the housing and separated from the drive coupling half by a separation wall portion of the housing; and a fluid conduit for communicating a portion of liquid refrigerant from the condenser to an inside surface of the separation wall portion. During operation, the liquid refrigerant from the condenser is evaporated on or adjacent the inside surface of the separation wall portion to thereby dissipate heat generated by magnetically induced eddy currents in the separation wall portion.

Abstract: A method of improving diagnosis, prognosis, or treatment includes accessing a digital health record, identifying, from the digital health record, an entry in which a replacement string or an additional string is to be suggested, determining a particular string to suggest as a replacement or addition to existing text in the entry, in response to suggesting the particular string, presenting a source of the particular string and one or more alternatives to the particular string, receiving an input indicating whether the particular string or the one or more alternatives are accepted, updating the entry based on the received input, and determining a medical diagnosis, prognosis, or treatment according to the updated entry. This method may provide diagnosis, prognosis, or treatment for COVID-19 patients.

Abstract: The invention concerns sensitive methods to measure mRNA levels in biopsied tumor tissues, including archived paraffin-embedded biopsy material. The invention also concerns breast cancer gene sets important in the diagnosis and treatment of breast cancer, and methods for assigning the most optimal treatment options to breast cancer patient based upon knowledge derived from gene expression studies.

Abstract: Provided are systems and methods that assist medical professionals, healthcare providers, patients and other users to identify medical calculators suitable for diagnosis, prognosis or treatment. Once identified, the systems and methods also facilitate the use of the calculator by the user with appropriate instructions and references, and recommendations to other potentially useful and relevant calculators.

Abstract: A device includes a first power over Ethernet (POE) port and a second POE port. One of the first POE port and the second POE port is configured as a primary port to supply power and another one of the first POE port and the second POE is configured as a redundant port to supply power. The supply of power through the primary POE port is disabled and supply of power through the redundant POE port is enabled responsive to the supply of power through the primary POE port being non-conformant with a given standard.

Abstract: Various health care services may be provided to a patient via a virtual nurse or interactive user application operating on a user computing device. One example method may include identifying a modification to a user's health care record stored in a database and identifying a new term included in the modification. The method may also include parsing the new term and comparing it to a predefined list of associated terms, retrieving an advertisement associated with the predefined list of associated terms which match the new term, and generating a message in the user's health care record with access to the advertisement.

Abstract: Various health care services may be provided to a patient via a virtual nurse or interactive user application operating on a user computing device. One example method may include identifying a modification to a user's health care record stored in a database, identifying one or more new terms included in the modification, creating a health care management record in a database responsive to the identified new term, and selecting content records to include in the user's health care management record.

Abstract: Various health care services may be provided to a patient via a virtual nurse or interactive user application operating on a user computing device. One example method may include receiving a recurring user health diagnostic at a server that stores user health records from a remote user computing device that receives and updates user health diagnostic data of a user on a recurring basis. The method may also include storing the user health diagnostic in a user patient data record of the server, and generating a health diagnostic history summary based on the at least one recurring user health diagnostic and updating the user patient data record to include the health diagnostic history.

Abstract: Various health care services may be provided to a patient via a virtual nurse or interactive user application operating on a user computing device. One example method may include identifying a medical prescription currently associated with a user's health care management record and identifying an initial dosage requirement of the medical prescription. The method may also include generating a series of recurring inquiries in the user's health care management record and receiving responses to the recurring inquires, and determining whether to create a dosage modification based on the responses.

Abstract: Various health care services may be provided to a patient via a virtual nurse or interactive user application operating on a user computing device. One example method may include receiving user input selections from inquiries generated to receive user input, generating a numerical score corresponding to each user input selection and incorporating the numerical scores with a user's primary health score. The method may also include determining whether the user's primary health score is above or below a predetermined health threshold, and creating a notification alert invoking a health care action if the user's primary health score exceeds or undercuts the health threshold.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of the general formula And their use in the treatment of psychotic disorders and cognitive impairment are disclosed.

Abstract: Compounds of general formula and their use in the treatment of psychotic disorders and cognitive impairment, are disclosed.

Abstract: Compounds of formula (I) and salts are provided: wherein R5 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; R6 is selected from halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano; and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R6 is selected from hydrogen, halogen, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6 alkoxy, C1-6 alkoxy substituted with one or more fluorine atoms, and cyano, and Q is hydrogen or C1-6alkyl. The compounds are M1 agonists and are useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts are provided: wherein R4 is fluoro, R5 is selected from hydrogen, halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C1-6alkoxy, and C1-6alkoxy substituted with one or more fluorine atoms; and R6 is selected from halogen, cyano, C1-6alkyl, C1-6alkyl substituted with one or more fluorine atoms, C3-6cycloalkyl, C3-6cycloalkyl substituted with one or more fluorine atoms, C1-6alkoxy and C1-6alkoxy substituted with one or more fluorine atoms, and Q is hydrogen or C1-6alkyl. The compounds are expected to be useful for therapy, for example in the treatment of psychotic disorders and cognitive impairment.

Abstract: Compounds of formula (I) and salts and solvates are provided: wherein Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: Compounds of formula (I), salts and solvates are provided: Uses of the compounds for therapy, for example in the treatment of psychotic disorders and cognitive impairment, are also disclosed.

Abstract: The present invention is directed to a much safer and less expensive way of providing portable oxygen from a gas concentrator for patients who do not want to be tied to a stationary machine or restricted by present oxygen technology. The present invention involves a home liquid oxygen ambulatory system for supplying a portable supply of oxygen, where a portion of the gaseous oxygen output obtained from an oxygen concentrator is condensed into liquid oxygen. The system includes an oxygen concentrator which separates oxygen gas from the ambient air, a condenser in communication with the oxygen concentrator for receiving and liquefying the oxygen gas flow, a cryocooler associated with the condenser, and a first storage dewar in fluid communication with the condenser and adapted to store the oxygen liquefied by the condenser, the first storage dewar including means for transferring liquid oxygen from the first dewar to a second dewar for storing a quantity of oxygen suitable for moveable oxygen treatment.