Abstract: A heat pump system includes a regenerative thermal machine (1*, 1**, 1***) in fluid communication with one or more heat reservoirs (21; 31), wherein the regenerative thermal machine (1, 1**, 1***) comprises working fluid compression (12) and expansion (11) spaces; and an electrical machine (130) that is electrically connectable via interconnector (3) to an electricity distribution grid (2); characterised in that the regenerative thermal machine (1*, 1**, 1***) further comprises a phase change means (160) operable to change the phase relationship between the said working fluid compression (12) and expansion spaces (11) of the regenerative thermal machine (1*, 1**, 1***).

Abstract: A heat pump system includes a regenerative thermal machine (1*, 1**, 1***) in fluid communication with one or more heat reservoirs (21; 31), wherein the regenerative thermal machine (1, 1**, 1***) comprises working fluid compression (12) and expansion (11) spaces; and an electrical machine (130) that is electrically connectable via interconnector (3) to an electricity distribution grid (2); characterised in that the regenerative thermal machine (1*, 1**, 1***) further comprises a phase change means (160) operable to change the phase relationship between the said working fluid compression (12) and expansion spaces (11) of the regenerative thermal machine (1*, 1**, 1***).

Abstract: An illustrative embodiment provides a computer-implemented process for navigation through historical stored interactions associated with a multi-user view that receives a previously saved multi-user view, wherein the multi-user view comprises a set of artifact attributes, receives an identified filter from a user, and presents a filtered view to the user. The process further determines whether to amend the filtered view, and responsive to a determination to amend the filtered view, generates an amended view from the filtered view, and responsive to a determination to save the amended view, saves the amended view as one of a new view or an updated view.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: A thermodynamic machine (1) of a Stirling type, the machine comprising an expansion chamber (5), a compression chamber (6), a regenerator (12) disposed between the expansion and compression chambers; a first heat exchanger (13) in communication with the expansion chamber and the regenerator; a second heat exchanger (14) in communication with the compression chamber and the regenerator; a first bypass conduit (15) connecting the expansion chamber with the regenerator bypassing the first heat exchanger; a second bypass conduit (16) connecting the compression chamber with the regenerator bypassing the second heat exchanger; at least a pair valves (18, 20, 22, 24), one valve (18, 20) provided between the expansion chamber and the first heat exchanger and/or between the regenerator and the first heat exchanger and/or in the first bypass conduit between the expansion chamber and the regenerator; and the other valve (22, 24) provided between the compression chamber and the second heat exchanger and/or between the re

Abstract: Techniques to glycosylation are described, and more particularly to the production of glycosylation structures that are resistant to enzymatic degradation, thereby modulating one or more of their biological properties or those of therapeutic moieties incorporating them, and in particular to reacting activated carbohydrate substrates containing fluorine, such as 3-fluoro sialic acid compounds, with sugar acceptors to produce covalent conjugates of the sugar acceptor and one or more of the sialic acid compounds.

Abstract: An illustrative embodiment provides a computer-implemented process for navigation through historical stored interactions associated with a multi-user view that receives a previously saved multi-user view, wherein the multi-user view comprises a set of artifact attributes, receives an identified filter from a user, and presents a filtered view to the user. The process further determines whether to amend the filtered view, and responsive to a determination to amend the filtered view, generates an amended view from the filtered view, and responsive to a determination to save the amended view, saves the amended view as one of a new view or an updated view.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: According to one aspect of the present disclosure an apparatus for navigation through historical stored interactions associated with a multi-user view includes a communications fabric, a memory connected to the communications fabric containing computer executable program code, and a processor unit connected to the communications fabric and executing the program code to direct the apparatus to: receive a previously saved multi-user view, wherein the multi-user view comprises a set of artifact attributes; receive an identified filter from a user; present a filtered view to the user; determine whether to amend the filtered view; responsive to a determination to amend the filtered view, generate an amended view from the filtered view; and responsive to a determination to save the amended view, save the amended view as one of a new view or an updated view.

Abstract: An illustrative embodiment provides a computer-implemented process for navigation through historical stored interactions associated with a multi-user view that receives a previously saved multi-user view, wherein the multi-user view comprises a set of artifact attributes, receives an identified filter from a user, and presents a filtered view to the user. The process further determines whether to amend the filtered view, and responsive to a determination to amend the filtered view, generates an amended view from the filtered view, and responsive to a determination to save the amended view, saves the amended view as one of a new view or an updated view.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: A thermodynamic machine (1) of a Stirling type, the machine comprising an expansion chamber (5), a compression in chamber (6), a regenerator (12) disposed between the expansion and compression chambers; a first heat exchanger (13) in communication with the expansion chamber and the regenerator; a second heat exchanger (14) in communication with the compression chamber and the regenerator; a first bypass conduit (15) connecting the expansion chamber with the regenerator bypassing the first heat exchanger; a second bypass conduit (16) connecting the compression chamber with the regenerator bypassing the second heat exchanger; at least a pair valves (18, 20, 22, 24), one valve (18, 20) provided between the expansion chamber and the first heat exchanger and/or between the regenerator and the first heat exchanger and/or in the first bypass conduit between the expansion chamber and the regenerator; and the other valve (22, 24) provided between the compression chamber and the second heat exchanger and/or between the

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: Reagents and methods for functionalizing polypeptides with moieties (alkylene glycol) molecules and glycan groups are disclosed that are based on a functionalizing reagent which comprises a nitrogen containing heterocyclic aromatic ring having a vinyl substituent that is capable of reacting with one or more thiol groups that are naturally present, or have been introduced into, the polypeptide, for example by employing a thiol group of one or more cysteine residues. The functionalizing reagent is covalently linked to a poly(alkylene glycol) molecule, such as a polyethylene glycol (PEG) molecule, or a glycan group so that the reaction between the vinyl group and the thiol group in the polypeptide covalently links the polypeptide to the poly(alkylene glycol) molecule and/or the glycan group.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.

Abstract: Compounds having a structure of Formula I and compositions comprising these compounds are provided. Uses of such compounds and compositions are provided for treatment or prophylaxis of viral infection. In particular, compounds and compositions may be for use in the treatment or prophylaxis of viral influenza.