Patents by Inventor Graham WHYTESIDE

Graham WHYTESIDE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • EXPRESSION CONTROL USING A REGULATABLE INTRON
    Publication number: 20230304003
    Abstract: The present invention relates to the use of a regulatory nucleic acid sequences that are able to regulate gene expression in eukaryotic cells and which are responsive to the unfolded protein response (UPR). There are disclosed regulatable introns and UPR-inducible promoters, which are able to regulate gene expression. There are also disclosed recombinant expression constructs comprising such regulatory nucleic acid sequences, whereby expression of the encoded expression product can be induced by invoking the unfolded protein response (UPR) in a eukaryotic cell containing the construct, methods of using such constructs and associated vectors, cells and suchlike.
    Type: Application
    Filed: November 4, 2022
    Publication date: September 28, 2023
    Applicant: ASKLEPIOS BIOPHARMACEUTICAL, INC.
    Inventor: Graham WHYTESIDE
  • FORSKOLIN-INDUCIBLE PROMOTERS AND HYPOXIA-INDUCIBLE PROMOTERS
    Publication number: 20230167458
    Abstract: The present invention relates to forskolin-inducible and hypoxia-inducible cis-regulatory elements, promoters and vectors, and methods of their use.
    Type: Application
    Filed: April 9, 2021
    Publication date: June 1, 2023
    Applicant: ASKLEPIOS BIOPHARMACEUTICAL, INC.
    Inventors: Graham WHYTESIDE, Victoria Fiona Torrance, Michael L. Roberts
  • LIVER-SPECIFIC INDUCIBLE PROMOTERS AND METHODS OF USE THEREOF
    Publication number: 20220111078
    Abstract: The present invention relates to inducible regulatory elements, promoters and vectors, especially gene therapy vectors, and methods of their use.
    Type: Application
    Filed: January 20, 2020
    Publication date: April 14, 2022
    Applicant: SYNPROMICS LIMITED
    Inventors: Michael ROBERTS, Graham WHYTESIDE, Anne BRAAE
  • EXPRESSION CONTROL USING A REGULATABLE INTRON
    Publication number: 20200199593
    Abstract: The present invention relates to the use of a regulatory nucleic acid sequences that are able to regulate gene expression in eukaryotic cells and which are responsive to the unfolded protein response (UPR). There are disclosed regulatable introns and UPR-inducible promoters, which are able to regulate gene expression. There are also disclosed recombinant expression constructs comprising such regulatory nucleic acid sequences, whereby expression of the encoded expression product can be induced by invoking the unfolded protein response (UPR) in a eukaryotic cell containing the construct, methods of using such constructs and associated vectors, cells and suchlike.
    Type: Application
    Filed: August 22, 2018
    Publication date: June 25, 2020
    Applicant: SYNPROMICS LIMITED
    Inventor: Graham WHYTESIDE