Patents by Inventor Graham Wynne

Graham Wynne has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinoline compounds
    Patent number: 9822078
    Abstract: The present invention relates to quinoline compounds as defined by Formula I below. Such quinoline compounds have been shown to inhibit the formation of amyloid deposits (e.g., amyloid oligomers, fibrils or plaques). Consequently, these compounds are suitable for treating a range of diseases and disorders in which amyloid deposits are implicated, such as type-2 diabetes and Alzheimer's disease.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: November 21, 2017
    Assignee: Oxford University Innovation Limited
    Inventors: David Vaux, Letitia Jean, Stephen Davies, Angela Russell, Graham Wynne, Carole Bataille, Méabh Brennan
  • QUINOLINE COMPOUNDS
    Publication number: 20170008849
    Abstract: The present invention relates to quinoline compounds as defined by Formula I below. Such quinoline compounds have been shown to inhibit the formation of amyloid deposits (e.g., amyloid oligomers, fibrils or plaques). Consequently, these compounds are suitable for treating a range of diseases and disorders in which amyloid deposits are implicated, such as type-2 diabetes and Alzheimer's disease.
    Type: Application
    Filed: February 27, 2015
    Publication date: January 12, 2017
    Inventors: David Vaux, Letitia Dean, Stephen Davies, Angela Russell, Graham Wynne, Carole Bataille, Méabh Brennan
  • Galactooligosaccharide composition and the preparation thereof
    Patent number: 7883874
    Abstract: Novel strains of Bifidobacterium hifidum capable of producing a novel galactosidase enzyme activity that converts lactose to a novel mixture of galactooligosaccharides. The mixture of oligosaccharidcs may be incorporated into numerous food products or animal feeds for improving gut health by promoting the growth of bifidobacteria in the gut, and repressing the growth of the pathogenic microflora.
    Type: Grant
    Filed: June 30, 2004
    Date of Patent: February 8, 2011
    Assignee: Clasado Inc.
    Inventors: Glenn Gibson, Jacek Witold Slupinski, Georgios Tzortzis, Anthony Graham Wynne
  • TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY
    Publication number: 20100267961
    Abstract: Provided is a process for the preparation of 5-(ethylsulfonyl)-2-(naphthalen-2-yl) benzo[d]oxazole useful in the treatment of Duchenne muscular dystrophy.
    Type: Application
    Filed: August 14, 2008
    Publication date: October 21, 2010
    Inventors: Graham Wynne, Alexander Weymouth-Wilson, Robert Clarkson, Renate Van Well, Stephen Wren, Olivier De Moor
  • N-substituted benzimidazolyl c-Kit inhibitors
    Publication number: 20060189629
    Abstract: Compounds represented by Formula (I): or a pharmaceutically acceptable salt or N-oxide thereof, are useful in the treatment of cancer.
    Type: Application
    Filed: August 16, 2004
    Publication date: August 24, 2006
    Inventors: Joshua Bolger, Arlindo Castelhano, Andrew Crew, Han-Qing Dong, Ayako Honda, Radoslaw Laufer, An-Hu Li, Kristen Mulvihill, Li Qiu, Colin Sambrook Smith, Yingchaun Sun, Graham Wynne, Tao Zhang
  • Integrin antagonists useful as anticancer agents
    Publication number: 20060116383
    Abstract: The invention relates to compounds of the Formula 1 and to pharmaceutically acceptable salts and solvates thereof, wherein A, X2, X4, X5 and X1 are as defined herein. The invention also relates to methods of treating abnormal cell growth in mammals by administering the compounds of Formula 1 and to pharmaceutical compositions for treating such disorders which contain the compounds of Formula 1.
    Type: Application
    Filed: November 9, 2005
    Publication date: June 1, 2006
    Inventors: Jason Bloxham, Gary Borzillo, Eric Collington, Shazia Sadiq, Colin Sambrook Smith, Chris Waller, Graham Wynne
  • Mercaptoamides as histone deacetylase inhibitors
    Publication number: 20060047123
    Abstract: Mercaptoamide compounds, represented by Formulas (IA), (IB), (IIA), and (IIB): or a pharmaceutically acceptable salt thereof, inhibit histone deacetylase enzyme and are useful for the treatment and/or prevention of various infections, cancerous diseases, and conditions.
    Type: Application
    Filed: September 2, 2005
    Publication date: March 2, 2006
    Inventors: Saleh Ahmed, Celine Combet, Scott Cuthill, Graham Dawson, William Gattrell, Mario Lobell, Neil Pegg, Imaad Saba, Simon Swain, Claire Thomas, Graham Wynne
  • (2-carboxamido)(3-amino) thiophene compounds
    Publication number: 20050154014
    Abstract: Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.
    Type: Application
    Filed: October 26, 2004
    Publication date: July 14, 2005
    Inventors: Jason Bloxham, Andrew Crew, Ayako Honda, An-Hu Li, Bijoy Panicker, Lawrence Tardibono, Graham Wynne
  • Process for preparing resorcinol derivatives
    Publication number: 20050143594
    Abstract: The present invention relates to an improved process for preparing 4-substituted resorcinol derivatives, and intermediate compounds useful in the preparation of such resorcinol derivatives.
    Type: Application
    Filed: January 14, 2005
    Publication date: June 30, 2005
    Inventors: Stuart Bradley, John Kitchin, Graham Wynne