Patents by Inventor Grahame James McKenzie

Grahame James McKenzie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening
    Patent number: 11821904
    Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.
    Type: Grant
    Filed: June 30, 2021
    Date of Patent: November 21, 2023
    Assignee: Phoremost Limited
    Inventors: Bryn Shaun Hardwick, Grahame James Mckenzie
  • METHODS OF SCREENING
    Publication number: 20220018848
    Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.
    Type: Application
    Filed: June 30, 2021
    Publication date: January 20, 2022
    Applicant: Phoremost Limited
    Inventors: Bryn Shaun HARDWICK, Grahame James MCKENZIE
  • TARGET FOR ANTI-CANCER THERAPY
    Publication number: 20210393667
    Abstract: The present invention relates to a composition and uses thereof. The invention relates to a composition for use in stimulating neoantigen production in a cancerous tumour. In particular, the composition comprises a compound or a pharmaceutically acceptable salt thereof, wherein the composition is a negative modulator of the expression, function or stability of ribonucleotide reductase.
    Type: Application
    Filed: October 16, 2019
    Publication date: December 23, 2021
    Applicant: Phoremost Limited
    Inventors: Grahame James MCKENZIE, Samuel Peter BARKER
  • Methods of screening
    Patent number: 11085926
    Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.
    Type: Grant
    Filed: December 22, 2016
    Date of Patent: August 10, 2021
    Assignee: Phoremost Limited
    Inventors: Bryn Shaun Hardwick, Grahame James McKenzie
  • METHODS OF SCREENING
    Publication number: 20190004058
    Abstract: The invention provides a method of identifying a peptide interaction site on a target protein wherein the target protein modulates the phenotype of a mammalian cell, using mammalian encoded peptides (SEPs) such as short open reading frame (sORF) encoded peptides. The invention further provides a method for the identification of new therapeutic targets and protein interaction sites for use in drug discovery.
    Type: Application
    Filed: December 22, 2016
    Publication date: January 3, 2019
    Inventors: Bryn Shaun HARDWICK, Grahame James MCKENZIE
  • A COMPOSITION COMPRISING A NOTCH LIGAND AND AN ALLERGENB OR ALLERGEN BYSTANDER ANTIGEN
    Publication number: 20100303867
    Abstract: A method is provided for reducing an immune response to an allergen or antigenic determinant thereof in a mammal by administering a modulator of the Notch signalling pathway.
    Type: Application
    Filed: April 23, 2010
    Publication date: December 2, 2010
    Inventors: MARK WILLIAM BODMER, EMMANUEL CYRILLE PASCAL BRIEND, BRIAN ROBERT CHAMPION, ANDREW CHRISTOPHER LENNARD, GRAHAME JAMES MCKENZIE, SILVIA RAGNO, TAMARA TUGAL, GEORGE ALBERT WARD, LESLEY LYNN YOUNG
  • Conjugates for the modulation of immune responses
    Publication number: 20040213797
    Abstract: A conjugate having first and second sequence, wherein the first sequence includes a polypeptide which is capable of binding to a MHC class II molecule and a polypeptide comprising a modulator of the Notch signalling pathway.
    Type: Application
    Filed: January 23, 2004
    Publication date: October 28, 2004
    Inventors: Mark William Bodmer, Brian Robert Champion, Grahame James McKenzie, Lucy Emma Nye