Patents by Inventor Grahame Woollam

Grahame Woollam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Crystalline freebase forms of a biphenyl compound
    Patent number: 11858898
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: May 19, 2023
    Date of Patent: January 2, 2024
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20230303492
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: May 19, 2023
    Publication date: September 28, 2023
    Inventor: Grahame WOOLLAM
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 11691948
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: April 15, 2021
    Date of Patent: July 4, 2023
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 11649209
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: June 15, 2022
    Date of Patent: May 16, 2023
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20220306580
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: June 15, 2022
    Publication date: September 29, 2022
    Inventor: Grahame WOOLLAM
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20220009890
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: April 15, 2021
    Publication date: January 13, 2022
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 11008289
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: December 16, 2019
    Date of Patent: May 18, 2021
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20200308116
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: December 16, 2019
    Publication date: October 1, 2020
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Novel Pyrazolo Pyrimidine Derivatives
    Publication number: 20200289514
    Abstract: The present invention describes new pyrazolo-pyrimidine derivatives which are generally interacting with MALT1 proteolytic and/or autoproteolytic activity, and in particular which may inhibit said activity. The present invention further describes the synthesis of said new pyrazolo-pyrimidine derivatives, their use as a medicament, especially by interacting with MALT1 proteolytic and/or autoproteolytic activity.
    Type: Application
    Filed: November 11, 2016
    Publication date: September 17, 2020
    Inventors: Karen KAMMERTOENS, Jean QUANCARD, Achim SCHLAPBACH, Oliver SIMIC, Marina TINTELNOT-BLOMLEY, Grahame WOOLLAM
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 10550081
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: September 13, 2018
    Date of Patent: February 4, 2020
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20190248743
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: September 13, 2018
    Publication date: August 15, 2019
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 10100013
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: August 15, 2017
    Date of Patent: October 16, 2018
    Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20180186740
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: August 15, 2017
    Publication date: July 5, 2018
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 9765028
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: July 11, 2016
    Date of Patent: September 19, 2017
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20170081283
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: July 11, 2016
    Publication date: March 23, 2017
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 9415041
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: December 1, 2015
    Date of Patent: August 16, 2016
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20160143897
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: December 1, 2015
    Publication date: May 26, 2016
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 9226896
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: November 19, 2014
    Date of Patent: January 5, 2016
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam
  • CRYSTALLINE FREEBASE FORMS OF A BIPHENYL COMPOUND
    Publication number: 20150164796
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Application
    Filed: November 19, 2014
    Publication date: June 18, 2015
    Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
    Inventor: Grahame Woollam
  • Crystalline freebase forms of a biphenyl compound
    Patent number: 8921396
    Abstract: The invention provides two crystalline freebase forms of biphenyl-2-ylcarbamic acid 1-(2-{[4-(4-carbamoylpiperidin-1-ylmethyl)benzoyl]methylamino}ethyl)piperidin-4-yl ester. The invention also provides pharmaceutical compositions comprising the crystalline freebase or prepared using the crystalline freebases; processes and intermediates for preparing the crystalline freebases; and methods of using the crystalline freebases to treat a pulmonary disorder.
    Type: Grant
    Filed: August 22, 2013
    Date of Patent: December 30, 2014
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventor: Grahame Woollam