Abstract: A footwear construction including a midsole frame having a forefoot base, a heel base and an intermediate frame section that connects the forefoot base and the heel base. The forefoot base and heel base can be separated from one another by a frame void. The forefoot base can include at least one forefoot base void extending across the width, of the footwear to improve flexibility of the footwear. The construction also can include a midsole including a lower surface housed at least partially within and/or joined with the midsole frame, with the midsole frame forefoot base and a heel base separated from one another below the midsole lower surface by the frame void, and connected above the lower surface by the intermediate frame section. Where the construction includes an outsole, that outsole can define an outsole forefoot void, which can be aligned with the forefoot base void.