Abstract: Machine learning techniques to optimize user interface template selection are provided. In one technique, a first set of feature values pertaining to a first entity is identified. Multiple sets of feature values are also identified, each set of feature values pertaining to a different user interface (UI) template for rendering content items on a computer screen. For each set of feature values of the multiple sets, the set of feature values and the first set of feature values are inserted into a machine-learned model to generate a score, which is added to a set of scores, which set of scores is initially empty. Based on the set of scores, a particular UI template is selected for a content item. The content item is transmitted over a computer network to be presented on a screen of a computing device of the first entity according to the particular UI template.